The Open Arthritis Journal
(Discontinued)
ISSN: 1876-5394 ― Volume 7, 2014
Dendritic Cells in Autoimmune Diseases
Mohan S. Maddur1, 2, 3, Janakiraman Vani1, 2, 3, Jordan D. Dimitrov1, 2, 3, Kithiganahalli N. Balaji4, Sébastien Lacroix-Desmazes1, 2, 3, Srini V. Kaveri1, 2, 3, Jagadeesh Bayry*, 1, 2, 3
1 Institut National de la Santé et de la Recherche Médicale, Unité 872, 15 rue de l’Ecole de Médicine, Paris, F-75006, France
2 Centre de Recherche des Cordeliers, Equipe 16- Immunopathology and Therapeutic Immunointervention, Université Pierre et Marie Curie – Paris 6, UMR S 872, 15 rue de l’Ecole de médicine, Paris, F-75006, France
Abstract
Dendritic cells (DCs) are professional antigen presenting cells, which play a crucial role both in maintaining immune tolerance and in inducing adaptive immune responses. Therefore, DCs are the most sought in inciting autoimmunity and its sustenance to autoimmune diseases. The emerging knowledge of the importance of DCs, DC-derived cytokines, and intracellular signal transduction pathways in mediating autoimmune diseases and in creating an inflammatory environment provides a rationale for pursuing strategies to block these inflammatory pathways for therapeutic purposes.
Keywords: Dendritic cells, Autoimmunity, Rheumatology, Rheumatoid Arthritis, Lupus, Kawasaki disease, T cells, cytokines, co-stimulation.
Article Information
Identifiers and Pagination:
Year: 2010Volume: 3
First Page: 1
Last Page: 7
Publisher Id: TOARTHJ-3-1
DOI: 10.2174/1876539401003010001
Article History:
Received Date: 19/5/2009Revision Received Date: 14/9/2009
Acceptance Date: 14/9/2009
Electronic publication date: 12/1/2010
Collection year: 2010
© Maddur et al.; Licensee Bentham Open.
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
* Address correspondence to this author at the INSERM U 872, Equipe 16, Centre de Recherche des Cordeliers, 15 rue de l’Ecole de Médicine, Paris, F-75006, France; Tel: 00 33 1 55 42 82 66; Fax: 00 33 1 55 42 82 62; E-mail: jagadeesh.bayry@crc.jussieu.fr
| Open Peer Review Details | |||
|---|---|---|---|
| Manuscript submitted on 19-5-2009 |
Original Manuscript | Dendritic Cells in Autoimmune Diseases | |
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