Human Papillomavirus Integration and its Role in Cervical Malignant Progression
Rachel Raybould*, Alison Fiander*, Sam Hibbitts*
Abstract
High risk Human Papilloma Virus (HR-HPV) DNA integration into the human genome is one of the key stages in the progression of cervical neoplasia. This mini-review highlights the importance of HPV integration as a potential biomarker for cervical screening and briefly describes the main methods used to detect HPV integration: Amplification of Papillomavirus Oncogene Transcripts (APOT), Restriction Site PCR (RS-PCR), Southern blot and Detection of Integrated Papillomavirus Sequences (DIPS). The potential mechanisms of HPV integration are discussed with a focus on DNA instability; site of integration; and transcriptional regulation of integrants. This article provides an overview of the role HPV integration plays in malignant progression
Keywords: Human Papillomavirus, integration, cervical cancer, E6 and E7.
Article Information
Article History:
Received Date: 01/09/2010
Revision Received Date: 26/11/2010
Acceptance Date: 27/11/2010
Electronic publication date: 25/1/2011
Collection year: 2011
© Raybould et al.; Licensee Bentham Open.
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (
http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
* Address correspondence to these authors at the Obstetrics and Gynaecology, School of Medicine, Cardiff University, CF14 4XN, UK; Tel: 029 2074 4742; E-mails: raybouldre1@cf.ac.uk, fianderan@cf.ac.uk , hibbittssj@cardiff.ac.uk
Open Peer Review Details |
Manuscript submitted on 01-09-2010 |
Original Manuscript |
Human Papillomavirus Integration and its Role in Cervical Malignant Progression |