The Open Cardiovascular Medicine Journal


ISSN: 1874-1924 ― Volume 10, 2016

HIV and HAART-Associated Dyslipidemia



Eoin R Feeney1, *, Patrick W.G Mallon 1, 2
1 HIV Molecular Research Group, School of Medicine and Medical Science, University College Dublin, Dublin, Ireland
2 Department of Infectious Diseases, Mater Misericordiae University Hospital, Dublin, Ireland

Abstract

Effective highly active antiretroviral therapy (HAART) for human immunodeficiency virus-1 (HIV) infection has led to marked improvement in life-expectancy for those infected with HIV. Despite reductions in the incidence of AIDS with effective treatment, patients continue to experience considerable morbidity and mortality from non-AIDS illness such as premature cardiovascular disease, liver failure and renal failure. These morbidities, particularly premature cardiovascular disease, are thought to be related to a combination of the effects of an ageing HIV-infected population coupled with long-term effects of HIV infection and antiretroviral therapy (ART). One of the principle drivers behind the well documented increase in the risk of cardiovascular disease in HIV-infected patients is dyslipidemia.

This review will focus on the clinical presentation of HIV and ART-associated dyslipidemia, what is known of its patho-physiology, including associations with use of specific antiretroviral medications, and suggest screening and management strategies.

Keywords: HIV, HAART, dyslipidemia, cholesterol, triglycerides, lipids..


Article Information


Identifiers and Pagination:

Year: 2011
Volume: 5
First Page: 49
Last Page: 63
Publisher Id: TOCMJ-5-49
DOI: 10.2174/1874192401105010049

Article History:

Received Date: 15/12/2010
Revision Received Date: 01/01/2011
Acceptance Date: 06/01/2011
Electronic publication date: 24/02/2011
Collection year: 2011

© Feeney and Mallon; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.


* Address correspondence to this author at the School of Medicine and Medical Science, University College Dublin, Dublin 2, Ireland; Tel: +353 1 7166518; Fax: +353 1 7166335; E-mail: eoin.feeney@ucd.ie


Society Accreditations


Endorsements




Aristofanis Gikas
Health Centre of Kalivia, K
alivia, Attiki,
Greece


SCImago Journal Ranking

SCImago Journal & Country Rank

Browse Contents


Webmaster Contact: urooj@benthamopen.com
Copyright © 2016 Bentham Open