The Open Dentistry Journal

ISSN: 1874-2106 ― Volume 10, 2016

Mast Cells and Angiogenesis in Oral Malignant and Premalignant Lesions

E.Z Michailidou, A.K Markopoulos*, D.Z Antoniades
Department of Oral Medicine and Maxillofacial Pathology, Aristotle University, Thessaloniki, Greece


Mast cell contribution to neoangiogenesis during tumorigenesis in oral squamous cell carcinoma is not determined yet. Objectives: To associate numerical mast cell density (MCD) to numerical microvessel density (MVD) during the progression of oral leukoplakia without dysplasia and leukoplakia with dysplasia to squamous cell carcinoma (OSCC). Materials and methods: MVD was analysed immunohistochemically (mouse monoclonal anti-human CD34) in 49 paraffin-embedded specimens, 35 OSCCs, 9 leukoplakias and 5 normal oral tissues. Toluidine blue counterstaining revealed mast cells. MCD and MVD were assessed at the same optical field. Results: MVD increased between: normal oral mucosa, dysplasia (p=0.004), OSCC (p=0.001), leukoplakia and OSCC (p=0.041). MCD increased between: normal oral mucosa, dysplasia (p=0.003), OSCC (p=0.000), leukoplakia and OSCC (p=0.007). MVD was found to depend on MCD (p=0.000) in a percent 28.3% (power curve fit model). Conclusions: Mast cells are attracted at the lesion site and may turn on an angiogenic switch during tumorigenesis in OSCC.

Article Information

Identifiers and Pagination:

Year: 2008
Volume: 2
First Page: 126
Last Page: 132
Publisher Id: TODENTJ-2-126
DOI: 10.2174/1874210600802010126

Article History:

Received Date: 31/3/2008
Revision Received Date: 8/8/2008
Acceptance Date: 24/10/2008
Electronic publication date: 28/11/2008
Collection year: 2008

© Michailidou et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Oral Medicine & Maxillofacial Pathology, School of Dentistry, Aristotle University, 54124 Thessaloniki, Greece; E-mail:


José Ricardo Kina
Department of Surgery and Integrated Clinic,
Araçatuba School of Dentistry, São Paulo State University

Mahtab Memarpour
Prevention of Oral and Dental Disease Research Center,
Department of Pediatric Dentistry, School of Dentistry,
Shiraz University of Medical Sciences, Shiraz,

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