Advances and Developments in the Use of Human Mesenchymal Stem Cells – A Few Considerations
Lucinda Kennard1, Gopiga Thanabalasundaram2, Hiteshkumar D Tailor*, 2, Wasim S Khan3
1 Foundation Training Department, East of England NHS Deanery, Cambridge, CB21 5XE, UK
2 University College London Medical School, Gower Street, London WC1E 6BT, UK
3 University College London Institute of Orthopaedics and Musculoskeletal Sciences, Royal National Orthopaedic Hospital, Stanmore, Middlesex, HA7 4LP, UK
One less visited area in musculoskeletal stem cell research is the effects of donor age on quality of stem cells. The prevalence of degenerative orthopaedic conditions is large, and the older population is likely to receive great benefit from stem cell therapies. There are many known growth factors involved in controlling and influencing stem cell growth which are also related to cell senescence. Of which, expressions are found to be altered in mesenchymal stem cells from older donors. Considerations must also be taken of these mechanisms which also have a role in cell cycle and tumour suppression.
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