The Open Virology Journal

ISSN: 1874-3579 ― Volume 9, 2015

Neutrophil Apoptosis During Viral Infections

Carole Elbim*, 1, Peter D Katsikis2, Jérôme Estaquier*, 3
1 Centre de Recherche des Cordeliers, Université Pierre et Marie Curie – Paris 6, UMR S 872, Paris, F-75006 France ; Université Paris Descartes, UMR S 872, Paris, F-75006 France ; INSERM, U872, Paris, F-75006, France
2 Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
3 INSERM U955, Faculté Créteil Henri Mondor, Créteil, F-94000, France


Apoptosis, or programmed cell death, is a highly conserved cellular suicide mechanism. Apoptosis is critical to the effective resolution of inflammation, particularly in regulating the lifespan of neutrophils. Neutrophils are key components of the first line of defense against microorganisms. Thus, subversion of this critical host defense mechanism by pathogens can contribute to susceptibility to severe and recurrent infections. In this review, we describe the molecular mechanisms involved in PMN death in relationship with viral infections.

Identifiers and Pagination:

Year: 2009
Volume: 3
First Page: 52
Last Page: 59
Publisher Id: TOVJ-3-52
DOI: 10.2174/1874357900903010052

Article History:

Received Date: 23/4/2009
Revision Received Date: 21/5/2009
Acceptance Date: 29/5/2009
Electronic publication date: 19/6/2009
Collection year: 2009

Article Information:

© Elbim et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http: // which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to these authors at the INSERM U955, Faculté Créteil Henri Mondor, 8 rue du Général Sarrail, 94010 Créteil, France; Tel: +33 1 49 81 36 72; E-mail:

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