Table 1: Comparison of Features and Performance of the Major Automated Patch Clamp Systems

System	Q-Patch	NPC-16	CytoPatch	IonWorks (HT / Quatto)	PatchXpress
Vender	Sophion	Nanion Technologies	Cytocentrics	MDS	MDS
Electrode type	Plannar, silicon	Plannar, glass	Plannar, quartz glasses	Planar, plastic	Planar, glass
Data points per day	1250-3500	150	200	3000	2000
Recording during application	Yes	Yes	Yes	No	Yes
Compound wash out	Yes	Yes	Yes	No	Yes
Seal resistance	>1GΩ	>1GΩ	>1GΩ	50-1000MΩ	>1GΩ
Intracellular perfusion	No	Yes	Yes	No	No
User intervention during experiment	No	Yes	No	No	No
Current clamp	No	Yes	Yes	No	No
Right-shifted IC50 values	Yes	No	No	Yes (especially lipophilic compounds)	Yes
Utilize complex protocols	Yes	Yes	Yes	No	Yes