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Respiratory Syncitial Virus (RSV) |
Human Cytomegalovirus (HCMV) |
| Virus-induced Pathology |
- Lower respiratory tract disease in infants
- Associated with respiratory distress
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- Belong to the Herpes family:persistence of the virus in a latent state and repeated reactivation
- Subclinically in immunocompetent individuals but fatal disease for immunocompromized patients
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| Characteristics |
- Accumulation of PMN in lower airways
- PMN production of IL-9 which increases mucus production by Goblet cells
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- Presence of activated-PMN
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| Mechanisms |
- Presence of the anti-apoptotic cytokine IL-6
- Interaction of ssRNA from RSV with TLR7/8 ?
- Activation of PI3K and NFκB signaling pathways
- Increased expression of the anti-apoptotic protein Mcl1
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- Interaction of the viral protein UL36 with apoptotic pathways
- Blockade of caspase 8 activation
- Inhibition of Fas ligand-mediated apoptosis
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| Consequences |
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- Exacerbation of inflammatory responses e.g. in intestinal tissue
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