Fig. (3) Effect of leaf extracts removal on the development of herpes viruses cytophatic effect (CPE). Vero cells were infected with 0.05 m.o.i. of HSV-1and treated with 500 µg/ml of C. fragrans ethanol leaf extract at the end of infection. The treatment was terminated at 1, 3 or 10 days p. i. CPE development was evaluated every 24 h by inverted microscopy and expressed as the percentage of damaged cells in the culture. Data are means ± SD of three independent experiments.