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The Open Pain Journal is an Open Access journal, which publishes original full length, reviews/mini-reviews, short research articles (letters) and guest edited single topic issues in all important areas of pain research including pain medicine, genetics, neurology, internal medicine, clinical pharmacology, child neuropediatrics, anesthesiology, rheumatology, otology, dentistry, neurotraumatology, neurosurgery, meta analyses of drugs for pain management and clinical studies.


The Open Pain Journal, a peer reviewed journal, is an important and reliable source of current information on recent developments in the field. Emphasis is placed on publishing quality papers, making them freely available to researchers worldwide.


Editor's Choice

Ligamentous Knee Joint Instability: Association with Chronic Conditions of the Knee and Treatment with Prolotherapy

Ross A. Hauser, Danielle Steilen-Matias, Johanna B. Lackner, Benjamin R. Rawlings, Jeevan Mann, Torin Grogan, Anna Phillips

Ligamentous knee joint instability and other conditions associated with knee dysfunction are common musculoskeletal complaints that affect a large percentage of the global population. A healthy knee has normal joint mechanics and can maintain its stability as it responds to the forces placed upon it. Once undue forces, whether from injury, wear and tear, or overuse, cause the soft tissue structures of the knee to stretch beyond their normal range of motion, they can become lax, elongated, damaged, or torn, especially the ligaments. This condition, known as ligamentous knee instability, causes destructive joint forces to occur, which results in the development of other pathophysiologic conditions related to knee dysfunction, including osteoarthritis, patellar pain syndromes, tendinopathies, meniscus tears, and osteochondral defects. Traditional treatments address the consequences of joint instability, such as synovitis and joint swelling, but do not address the underlying ligament and/or disease that led to the joint instability. Prolotherapy promotes the repair of injured or degenerated tissues, such as ligaments, tendons, and menisci, by stimulating the physiological healing process of the joint. This process corrects the underlying joint instability, reduces associated pain, improves knee function, and has the potential to slow the degenerative process.

November 15, 2023
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