Sex-Related Differences in Plasma Oxytocin Levels in Humans

Marazziti, Donatella; Baroni, Stefano; Mucci, Federico; Piccinni, Armando; Moroni, Ilenia; Giannaccini, Gino; Carmassi, Claudia; Massimetti, Enrico; Dell’Osso, Liliana

Sex-Related Differences in Plasma Oxytocin Levels in Humans

Donatella Marazziti^{1, *}, Stefano Baroni¹, Federico Mucci¹, Armando Piccinni¹, Ilenia Moroni¹, Gino Giannaccini², Claudia Carmassi¹, Enrico Massimetti³, Liliana Dell’Osso¹

¹ Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry, University of Pisa, Pisa, Italy

² Dipartimento di Farmacia, University of Pisa, Pisa, Italy

³ ASST, Bergamo Ovest, SSD Servizio Psichiatrico diagnosi e cura, Treviglio, Italy

Article Information

Identifiers and Pagination:

Year: 2019
Volume: 15
First Page: 58
Last Page: 63
Publisher ID: CPEMH-15-58
DOI: 10.2174/1745017901915010058

Article History:

Received Date: 23/01/2019
Revision Received Date: 19/02/2019
Acceptance Date: 22/02/2019
Electronic publication date: 26/03/2019
Collection year: 2019

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© 2019 Marazziti et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

^* Address correspondence to this author at the Dr. Donatella Marazziti, Dipartimento di Medicina Clinica e Sperimentale, Section of Psichiatry, University of Pisa, Via Roma, 67, 56100 Pisa, Italy; Tel: +39 050 2219768;Fax: +39 050 2219787; E-mail: dmarazzi@psico.med.unipi.it

Background:

Increasing evidence supports a key role of Oxytocin (OT) as a modulator of social relationships in mammals.

Objective:

The aim of the present study was to investigate possible sex-related differences in plasma OT levels in human beings.

Methods:

Forty-five healthy men and 45 women (mean age: 34.9 ± 6.2 years), were included in the study. Plasma preparation, peptide extraction and OT radioimmunoassay were carried out according to standardized methods.

Results:

The results showed that OT plasma levels (pg ̸ ml, mean ± SD) were significantly higher in women than in men (4.53 ± 1.18 vs 1.53 ± 1.19, p ˂ 0.001).

Conclusions:

The present finding demonstrates sex-related differences in plasma OT levels in humans. It is tempting to hypothesize that such differences might be related to behaviours, attitudes, as well as susceptibility to stress response, resilience and social emotions specific of women and men.

Keywords: Dymorphic changes, Humans, Oxytocin, Plasma levels, Social emotions, AVP receptors.

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Professor Mauro Giovanni Carta is a prominent researcher and author in the field of psychiatry, having published more than 200 publications in various international journals. Prof. Carta holds various key positions in the University of Cagliari, Italy, and other renowned organizations. He serves as a Full Professor of Translational Medicine at the University of Cagliari; the Head of Liaison Psychiatric Unit at University Hospital of Cagliari; Co-chairman at WHO-Geneva and University of Cagliari agreement for implementing the Quality Rights Project in the Mediterranean Area; the Head of a Collaborating Unit, Chafea – European Union, Joint Action on Mental Health, University of Cagliari; and the President of the Mediterranean Society on Mental Health.

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RESEARCH ARTICLE

Sex-Related Differences in Plasma Oxytocin Levels in Humans

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Abstract

Background:

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Conclusions:

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Published Contents

About the Editor

About the Journal

Clinical Practice & Epidemiology in Mental Health

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Unique Views/Downloads: 206,504

Press Release

Professor Mauro Giovanni Carta Receives Honorary Membership of the National Academy of Medicine of Brazil

Bentham Open Welcomes Sultan Idris University of Education (UPSI) as Institutional Member

Ministry Of Health, Jordan joins Bentham Open as Institutional Member

Porto University joins Bentham Open as Institutional Member

Join Our Editorial Board

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