Quality of Life and Psychiatric Symptoms in Wilson’s Disease: the Relevance of Bipolar Disorders

Carta, MG; Mura, G; Sorbello, O; Farina, G; Demelia, L

Quality of Life and Psychiatric Symptoms in Wilson’s Disease: the Relevance of Bipolar Disorders

MG Carta^{1, *}, G Mura¹, O Sorbello², G Farina¹, L Demelia²

¹ Centro di Psichiatria di Consultazione e Psicosomatica, University Hospital Cagliari, Italy

² UOC Gastroenterologia, AOU Cagliari, University Hospital Cagliari, Italy

Article Information

Identifiers and Pagination:

Year: 2012
Volume: 8
First Page: 102
Last Page: 109
Publisher ID: CPEMH-8-102
DOI: 10.2174/1745017901208010102

Article History:

Received Date: 7/5/2012
Revision Received Date: 20/5/2012
Acceptance Date: 28/5/2012
Electronic publication date: 18/9/2012
Collection year: 2012

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© Carta et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

^* Address correspondence to this author at the Centro di Psichiatria di Consultazione e Psicosomatica, University Hospital, Cagliari, Italy; Tel/Fax: +390706093498; E-mail: mgcarta@tiscali.it

Introduction:

Wilson’s disease is an inherited disorder caused by a gene located on chromosome 13, which involved copper transportation across cell membranes. The disease can cause a reduced incorporation of copper into ceruloplasmin resulting in accumulation of this metal in the liver, central nervous system, kidneys and other organs. The objective is to define the frequencies of psychiatric disorders in WD, the amount of impairment of Quality of Life [QoL] in patients with WD and the relevance of the psychiatric disorders in the QoL of people suffering by WD.

Methods:

This is a systematic review. The search of the significant articles was carried out in PubMed using specific key words.

Results:

Such other neurological diseases, WD is characterized by chronic course and need of treatments, impairment of functional outcomes and high frequency of psychiatric symptoms, although a specific association between Bipolar Disorders and WD was recently found. Despite this, since today few studies are carried on WD patients’ quality of life related to psychiatric symptoms. Some new reports showed a link between presence of Bipolar Disorders diagnosis, cerebral damage and low Qol.

Conclusion:

Prospective studies on large cohorts are required to establish the effective impact of psychiatric disorders comorbidity, particularly Bipolar Disorders, on quality of life in WD and to clarify the causal link between brain damage, psychiatric disorders and worsening of QoL.

Keywords: Wilson’s disease, psychiatric symptoms, quality of life, bipolar disorders, copper.

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Mauro G. Carta

Department of Public Health
University of Cagliari
Cagliari, CA
Italy

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Clinical Practice & Epidemiology in Mental Health
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Professor Mauro Giovanni Carta is a prominent researcher and author in the field of psychiatry, having published more than 200 publications in various international journals. Prof. Carta holds various key positions in the University of Cagliari, Italy, and other renowned organizations. He serves as a Full Professor of Translational Medicine at the University of Cagliari; the Head of Liaison Psychiatric Unit at University Hospital of Cagliari; Co-chairman at WHO-Geneva and University of Cagliari agreement for implementing the Quality Rights Project in the Mediterranean Area; the Head of a Collaborating Unit, Chafea – European Union, Joint Action on Mental Health, University of Cagliari; and the President of the Mediterranean Society on Mental Health.

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RESEARCH ARTICLE

Quality of Life and Psychiatric Symptoms in Wilson’s Disease: the Relevance of Bipolar Disorders

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Clinical Practice & Epidemiology in Mental Health

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Press Release

Professor Mauro Giovanni Carta Receives Honorary Membership of the National Academy of Medicine of Brazil

Bentham Open Welcomes Sultan Idris University of Education (UPSI) as Institutional Member

Ministry Of Health, Jordan joins Bentham Open as Institutional Member

Porto University joins Bentham Open as Institutional Member

Join Our Editorial Board

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