Open Medicine Journal




ISSN: 1874-2203 ― Volume 6, 2019

Did Oncotype DX® Recurrence Score Accurately Predict the Risk of Recurrence in Breast Cancer? A 10 Year Period Study in a Single Institution



Vanda Farahmand Torous , Sophia K Apple*
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA

Abstract

The 21-gene Recurrence Score (RS) assay (Oncotype DX®) predicts the risk of recurrence and benefit from chemotherapy in estrogen receptor (ER) positive, Her-2/neu negative, node negative and, more recently, limited node-positive (≤3) breast cancer. The 21-gene RS is divided into low, intermediate and high risk groups corresponding to a likelihood of recurrence within 10 years of initial diagnosis. Clinicians utilize 21-gene RS to guide treatment, particularly whether to add adjuvant chemotherapy to endocrine therapy. This study aimed to determine if 21-gene RS accurately predicts the rate of recurrence with respect to each category. A cohort of 236 patients was studied retrospectively and analyzed, based on correlation between histologic and immunohistochemical (IHC) findings versus 21-gene RS stratification in relation to clinical outcomes.

In the cohort examined, no deaths occurred in all the patients studied. Six patients had recurrence or metastatic disease. Of these six patients, only one had been stratified to the high risk group by 21-gene RS analysis, while four were stratified to the low risk group, and one to the intermediate risk group. 21-gene RS accurately predicted 97% of the low RS stratified patients to avoid receiving chemotherapy. However, addition of chemotherapy in the treatment regimen for node positive, Her-2/neu positive, high Ki-67, and PR negative tumors may be beneficial regardless of 21-gene RS. Our investigation found that there is a high concordance rate between 21-gene RS and IHC of ER, progesterone receptor (PR), and Her-2/neu.

Keywords: 21-gene Recurrence score, breast cancer, chemotherapy, Oncotype DX .


Article Information


Identifiers and Pagination:

Year: 2015
Volume: 2
First Page: 37
Last Page: 42
Publisher Id: MEDJ-2-37
DOI: 10.2174/1874220301401010037

Article History:

Received Date: 9/5/2015
Revision Received Date: 1/7/2015
Acceptance Date: 14/7/2015
Electronic publication date: 31/7/2015
Collection year: 2015

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© Torous and Apple; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.


* Address correspondence to this author at the Department of Pathology, UCLA Medical Center, Los Angeles, CA 90095, USA; Tel: 310-825-9288; Fax: 310-794-4161; E-mail: sapple@mednet.ucla.edu


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