RESEARCH ARTICLE
Gender Differences and Treatment Outcome among Drug Induced Hepatotoxicity Tuberculosis Patients
Kamini Nadarajah1, Amer Hayat khan1, *, Irfhan Ali1, 2, Raja Ahsan Aftab1, 3, *, Imam Shaik4
Article Information
Identifiers and Pagination:
Year: 2019Volume: 6
First Page: 26
Last Page: 32
Publisher ID: MEDJ-6-26
DOI: 10.2174/1874220301906010026
Article History:
Received Date: 09/02/2019Revision Received Date: 05/04/2019
Acceptance Date: 19/04/2019
Electronic publication date: 30/04/2019
Collection year: 2019
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Aims and Objective:
The aim of the current manuscript is to determine the association between gender differences and drug-induced hepatotoxicity among patients receiving anti-tuberculosis therapy and to determine the outcome of the treatment.
Methods:
A retrospective observational study was conducted among tuberculosis patients at Respiratory Clinic of Penang General Hospital (PGH) and Bukit Mertajam Hospital. A validated data collection instrument was used to collect patients’ demographic and clinical data confirmation of drug induced hepatotoxicity among tuberculosis patients was based on biochemical criteria which included 3 fold increase in liver enzymes in response to anti TB medication. All results were analyzed through SPSS version 20.
Results:
The study subjects were predominantly males 146 (76.8%) than females 44 (23.2%). Drug-induced hepatotoxicity with anti-tuberculosis drugs was observed the most among Chinese 90 (47%) ethnicity. Eighty-five (72%) male and 33 female (28%) tuberculosis drug-induced (TB-DIH) patients had a successful treatment outcome. Female patients had a statistically significant positive association with successful TB-DIH treatment outcomes (OR=1.83, 0.988-3.390 95%CI). Upon multivariate analysis, Indian ethnicity (OR = 0.173, p = 0.024), patients with relapse of Tuberculosis (TB) (OR= 0.332, p = 0.032) and Human Immune Virus (HIV) (OR= 0.217, p = 0.027) were less likely to have successful TB-DIH treatment outcomes.
Conclusion:
Female Tuberculosis Drug Induced Hepatotoxicity (TB DIH) patients were more likely to have successful treatment outcomes. A number of factors such as Indian ethnicity, patients with relapse of Tuberculosis (TB) and patients with Human Immune Virus (HIV) were less likely to have successful TB DIH treatment outcomes.