RESEARCH ARTICLE


Interaction between Urinary 11 Dehydrothromboxane B2 and Some Other Risk Factors in the Occurrence of Cerebral Infarction



Wang Lingling1, Chen Guixin1, Li Wei1, Sun Hua2, *
1 Department of Neurology, Affiliated Hospital of Beihua University, Jilin, 132011, China
2 Department of Endocrinology, Affiliated Hospital of Beihua University, Jilin, Jilin, 132001, China


Article Metrics

CrossRef Citations:
2
Total Statistics:

Full-Text HTML Views: 2002
Abstract HTML Views: 817
PDF Downloads: 445
ePub Downloads: 377
Total Views/Downloads: 3641
Unique Statistics:

Full-Text HTML Views: 777
Abstract HTML Views: 509
PDF Downloads: 317
ePub Downloads: 265
Total Views/Downloads: 1868



Creative Commons License
© 2019 Lingling et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Endocrinology, Affiliated Hospital of Beihua University, Jilin, Jilin, 132011, China;
Tel: 15643217009; E-mail: 373049083@qq.com


Abstract

Objective:

The objective of this study is to analyze the interaction between the urinary 11-dehydrothromboxane B2 (11-DH-TXB2) content and the smoking, drinking, hypertension or diabetes history of patients with cerebral infarction, and to determine the value of 11-DH-TXB2 in the occurrence and prevention of cerebral infarction.

Methods:

117 patients with cerebral infarction and 50 healthy controls were selected. Their general information, including smoking, drinking, hypertension and diabetes history, was analyzed, and their urinary11-DH-TXB2 contents were measured. The difference in the urinary 11-DH-TXB2 content between the two groups, and the additive model of the interaction between the urinary 11-DH-TXB2 content and other risk factors of cerebrovascular diseases were statistically analyzed.

Results:

There was no significant difference in the general information between the two groups (P > 0.05). Significant differences were observed in the urinary 11-DH-TXB2 content, and the smoking, diabetes and hypertension history between the two groups, while there was no significant difference in the drinking history between the two groups. The analysis of the interaction additive model showed that the OR value was 1, the synergy index (S) of increased 11-DH-TXB2 and smoking history was 1.219, the S of increased 11-DHTXB2 and hypertension history was 5.578 and that of increased 11-DH-TXB2 and the diabetes history was 4.604.

Conclusion:

There is a correlation between the urinary 11-DH-TXB2 content and the occurrence of cerebral infarction, and there is a synergistic interaction between the urinary DH-TXB2 content and the smoking, hypertension or diabetes history of patients with cerebral infarction. The increased 11-DH-TXB2 may be a risk factor for cerebral infarction and the urinary 11-DHTXB2 content can be used as an index to predict the occurrence and progression of cerebral infarction.

Keywords: Urine 11-dehydrothromboxane B2, Thromboxane A2, Cerebral infarction, Risk factors, Hypertension, Synergy index.