RESEARCH ARTICLE
Interaction between Urinary 11 Dehydrothromboxane B2 and Some Other Risk Factors in the Occurrence of Cerebral Infarction
Wang Lingling1, Chen Guixin1, Li Wei1, Sun Hua2, *
Article Information
Identifiers and Pagination:
Year: 2019Volume: 6
First Page: 89
Last Page: 93
Publisher ID: MEDJ-6-89
DOI: 10.2174/1874220301603010089
Article History:
Received Date: 12/07/2019Revision Received Date: 10/10/2019
Acceptance Date: 16/10/2019
Electronic publication date: 15/11/2019
Collection year: 2019
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Objective:
The objective of this study is to analyze the interaction between the urinary 11-dehydrothromboxane B2 (11-DH-TXB2) content and the smoking, drinking, hypertension or diabetes history of patients with cerebral infarction, and to determine the value of 11-DH-TXB2 in the occurrence and prevention of cerebral infarction.
Methods:
117 patients with cerebral infarction and 50 healthy controls were selected. Their general information, including smoking, drinking, hypertension and diabetes history, was analyzed, and their urinary11-DH-TXB2 contents were measured. The difference in the urinary 11-DH-TXB2 content between the two groups, and the additive model of the interaction between the urinary 11-DH-TXB2 content and other risk factors of cerebrovascular diseases were statistically analyzed.
Results:
There was no significant difference in the general information between the two groups (P > 0.05). Significant differences were observed in the urinary 11-DH-TXB2 content, and the smoking, diabetes and hypertension history between the two groups, while there was no significant difference in the drinking history between the two groups. The analysis of the interaction additive model showed that the OR value was 1, the synergy index (S) of increased 11-DH-TXB2 and smoking history was 1.219, the S of increased 11-DHTXB2 and hypertension history was 5.578 and that of increased 11-DH-TXB2 and the diabetes history was 4.604.
Conclusion:
There is a correlation between the urinary 11-DH-TXB2 content and the occurrence of cerebral infarction, and there is a synergistic interaction between the urinary DH-TXB2 content and the smoking, hypertension or diabetes history of patients with cerebral infarction. The increased 11-DH-TXB2 may be a risk factor for cerebral infarction and the urinary 11-DHTXB2 content can be used as an index to predict the occurrence and progression of cerebral infarction.