Open Medicine Journal

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Mean Platelet Volume and Red Cell Distribution Width in Differentiated Thyroid Cancer Patients

Hilal Kiziltunc Ozmen1, *, Seda Askin2, Eda Simsek3, Ayse Carlioglu4, Şenay Arikan4, Mustafa Utlu4
1 Department of Radiation Oncology, Faculty of Medicine, Ataturk Unıversity, Erzurum, Turkey
2 Department of Medical Biochemistry, Faculty of Medicine, Ataturk Unıversity, Erzurum, Turkey
3 Department of Otorhinolaryngology, Regional Training and Research Hospital, Erzurum, Turkey
4 Department of Endocrinology, Regional Training and Research Hospital, Erzurum, Turkey



The purpose of this study was to investigate MPV and RDW values in DTC patients.


Differentiated Thyroid Cancer (DTC) is subdivided into papillary, follicular and papillary micro thyroid cancers. Mean Platelet Volume (MPV) and red cell distribution width (RDW) are markers which have been investigated in many cancers, but no data are available for DTC.


MPV and RDW values were assessed in 108 patients with DTC, consisting of 44 with Papillary Thyroid Cancer (PTC) (mean age 43±13.9 years), 34 with Papillary Micro Thyroid Cancer (PmTC) (mean age 43.1 ± 10.6), and 28 with Follicular Cancer (FC) (mean age 46.9±12.5), and 77 control subjects (mean age 47.5±5.9).


The patient and control groups were matched in terms of age, and body mass index. All subjects were investigated using platelet and biochemical parameters.


Both MPV [(PTC, PmTC, and FC) (p=0.000, p=0.000 and p=0.001, respectively)] and RDW (PTC, PmTC, and FC) (p=0.02, p=0.04 and p=0.02, respectively)] values increased in patients with DTC compared to the controls. MPV values were significantly positively correlated with CRP (r=0.247; p=0.043), postoperative thyroglobulin (r=0.246; p=0.03), gamma glutamyl transferase (r=0.024; p=0.762), tumor size (r=0.209; p=0.047) and RDW (r=0.207; p=0.005). Age, gender, total cholesterol, and C-reactive protein were identified as independent predictors of MPV. Adjustment for other these factors produced no alteration in these relative risks at multiple regression analysis.


Our results suggest that patients with DTC have higher MPV and RDW values than healthy controls. MPV may represent a good follow-up criterion in DTC patients because of its positive correlation with tumor size and thyroglobulin.

Keywords: Mean platelet volume, RDW, Papillary micro thyroid cancer, Papillary thyroid carcinoma, Follicular thyroid carcinoma, Differentiated thyroid cancer.

Article Information

Identifiers and Pagination:

Year: 2019
Volume: 6
First Page: 94
Last Page: 100
Publisher Id: MEDJ-6-94
DOI: 10.2174/1874220301603010094

Article History:

Received Date: 03/09/2019
Revision Received Date: 18/10/2019
Acceptance Date: 29/10/2019
Electronic publication date: 20/12/2019
Collection year: 2019

© 2019 Ozmen et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Radiation Oncology, Faculty of Medicine, Ataturk University, 25240 Erzurum, Turkey;
Tel: +90 4423446696; E-mail:

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