Multiparticulate systems (pellets) of prasugrel hydrochloride were prepared by extrusion spheronization
method using MCC (micro crystalline cellulose). Optimum spheronization time and method of drying were selected as the
process parameters for the preparation of final batches. Various pellet properties were evaluated like size & shape analysis,
flow properties, bulk & tapped density, friability, moisture content, drug content, in vitro release rate and in vivo
pharmacodynamic studies. All pellet batches showed a narrow particle size distribution, good sphericity and excellent
flow properties. Drug content and moisture content of different pellet batches were found in specified limits. The release
kinetics of drug loaded MCC pellets followed Peppas model with Fickian diffusion of prasugrel from the pellets. In vivo
pharmacodynamic studies exhibited improved bleeding time in pellet group when compared with the marketed tablet formulation.
This is an open access article licensed under the terms of the (https://creativecommons.org/licenses/by/4.0/legalcode), which permits unrestricted, noncommercial
use, distribution and reproduction in any medium, provided the work is properly cited.
* Address correspondence to this author at the UIPS, Panjab University,
Chandigarh 160014, India; Tel: +91 172 2534101; Fax: +91 172 2543101;