The Open AIDS Journal

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Auditing National HIV Guidelines and Policies: The United Kingdom CD4 Surveillance Scheme

Alison E Brown* , Meaghan M Kall, Ruth D Smith, Zheng Yin, Alan Hunter, Alan Hunter, Valerie C Delpech
Health Protection Agency, Colindale, 61 Colindale Avenue, London, NW9 5EQ, UK


The United Kingdom’s CD4 surveillance scheme monitors CD4 cell counts among HIV patients and is a national resource for HIV surveillance. It has driven public health policy and allowed auditing of national HIV testing, treatment and care guidelines.

We demonstrate its utility through four example outputs: median CD4 count at HIV diagnosis; late HIV diagnosis and short-term mortality; the timing of first CD4 count to indicate entry into HIV care; and the proportion of patients with CD4 counts <350 cells/mm3 receiving anti-retroviral therapy (ARV).

In 2009, 95% (61,502/64,420) of adults living with diagnosed HIV infection had CD4 counts available. The median CD4 count at diagnosis increased from 276 to 335 cells/mm3 between 2000 and 2009, indicating modest improvements in HIV testing. In 2009, 52% of patients were diagnosed at a late stage of HIV infection (CD4 <350 cells/mm3); these individuals had a ten-fold risk of dying within a year of their diagnosis compared to those diagnosed promptly. In 2008, the national target of performing a CD4 count within 14 days of diagnosis was met for 61% of patients. National treatment guidelines have largely been met with 83% patients with CD4 <350 cells/mm3 receiving ARV.

The monitoring of CD4 counts is critical to HIV surveillance in the United Kingdom enabling the close monitoring of efforts to reduce morbidity and mortality associated with late diagnosis and underpins the auditing of policies and guidelines. These routine surveillance outputs can be generated at national and local levels to drive and monitor public health policy and prevention efforts.

Keywords:: Surveillance, CD4 counts, patient outcomes, United Kingdom..

Article Information

Identifiers and Pagination:

Year: 2012
Volume: 6
Issue: Suppl 1
First Page: 149
Last Page: 155
Publisher Id: TOAIDJ-6-149
DOI: 10.2174/1874613601206010149

Article History:

Received Date: 28/4/2011
Revision Received Date: 18/8/2011
Acceptance Date: 17/9/2011
Electronic publication date: 7/9/2012
Collection year: 2012

© Brown et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Health Protection Agency, Colindale, 61 Colindale Avenue, London, NW9 5EQ, UK; Tel: 020 83277559; E-mail:

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