The Open Anesthesia Journal

Formerly: The Open Anesthesiology Journal

ISSN: 2589-6458 ― Volume 14, 2020

Effect of Pentoxifylline on Organ Dysfunction and Mortality in Severe Sepsis

Hanaa A. Elgendy1, Haytham M. Ibrahim2, Bahaa Eldeen E. Hasan1, Amr Sobhy A. Elkawe1, *
1 Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2 Department of Critical Care, Maadi Military Hospital, Cairo, Egypt



Sepsis and infection are among the leading causes of death world-wide. The annual burden of sepsis in high-income countries is rising with a mortality rate of 40% and 90% of the worldwide deaths from pneumonia, meningitis or other infections occur in less developed countries. This study was performed to evaluate the therapeutic efficacy of pentoxifylline as an adjuvant therapy in septic patients and its effect on multiple organ dysfunction and mortality in septic patients.


This randomized, double-blinded prospective study was conducted from October 2017 to November 2018, which included a total sample size of 52 cases of septic patients. Organ dysfunction was used as a primary outcome with proposed large effect size ((0.8) and alfa =0.05 and power=0.80, so, 26 cases were needed in each group). Secondary outcomes were inflammatory markers C-Reactive Protein (CRP) and pro-calcitonin, duration of hospital stay, need for hemodialysis, need for vasopressor & inotropes, need for mechanical ventilation and 28 days survival.


Fifty-two patients with sepsis were divided in 1: 1 ratio to receive pentoxifylline or not. The average age of the included patients was almost 53 years, chest disorders were the main cause of sepsis in both groups. There were no statistically significant differences between both groups in terms of Sequential Organ Failure Assessment (SOFA) score, lactate level, CRP level and pro-calcitonin level. As regards secondary outcomes, there were no statistically significant differences between study’s groups in terms of length of hospital stay (p =0.707), need for hemodialysis (p =0.541), need for vasopressor & inotropes (p =0.249), need for mechanical ventilation (p =0.703), and 28 days survival (p =0.5).


We concluded that pentoxifylline as an adjuvant therapy in septic patients had no significant influence on multiple organ dysfunction and mortality.

Keywords: CRP , Mortality , Pentoxifylline , Procalcitonin , Sepsis , SOFA .

Article Information

Identifiers and Pagination:

Year: 2020
Volume: 14
First Page: 14
Last Page: 21
Publisher Id: TOATJ-14-14
DOI: 10.2174/2589645802014010014

Article History:

Received Date: 11/12/2019
Revision Received Date: 24/01/2020
Acceptance Date: 22/02/2020
Electronic publication date: 23/05/2020
Collection year: 2020

© 2020 Elgendy et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Faculty of Medicine, Ain Shams University, anesthesia, intensive care and pain management, Cairo, Egypt; Tel: 00201063394383, E-mail:

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