1 Department of Physics, Durham University, South Road, Durham, DH1 3LE, UK
2 University of Manchester, Manchester, M13 9PL, UK
We have characterized a broad range of liposome formulations with varying DcChol:DOPE ratio. Subsequent addition of DcChol to liposomes increases its positive surface charge. However, loading the nuclear acids did not neutralize the overall negative surface potential to a similar extent. The liposomes were tested by transfection of DNA in living cancer cells.
Received Date: 13/8/2007 Revision Received Date: 3/10/2007 Acceptance Date: 3/10/2007 Electronic publication date: 26/10/2007 Collection year: 2007
Full-Text HTML Views: 601 Abstract HTML Views: 393 PDF Downloads: 160 Total Views/Downloads: 1154
Full-Text HTML Views: 304 Abstract HTML Views: 192 PDF Downloads: 111 Total Views/Downloads: 607 Geographical View
2007 Bentham Science Publishers Ltd.
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/) which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
* Address correspondence to this author at the Department of Physics, Durham University, South Road, Durham, DH1 3LE, UK; E-mail: email@example.com