1 Department of Physics, Durham University, South Road, Durham, DH1 3LE, UK
2 University of Manchester, Manchester, M13 9PL, UK
We have characterized a broad range of liposome formulations with varying DcChol:DOPE ratio. Subsequent addition of DcChol to liposomes increases its positive surface charge. However, loading the nuclear acids did not neutralize the overall negative surface potential to a similar extent. The liposomes were tested by transfection of DNA in living cancer cells.
Received Date: 13/8/2007 Revision Received Date: 3/10/2007 Acceptance Date: 3/10/2007 Electronic publication date: 26/10/2007 Collection year: 2007
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