RESEARCH ARTICLE
Characterization of Liposomes for Cancer Cell Transfection
Svetlana A Tatarkova*, 1, Satvinder Khaira2
Article Information
Identifiers and Pagination:
Year: 2007Volume: 1
First Page: 60
Last Page: 63
Publisher ID: TOBEJ-1-60
DOI: 10.2174/1874120700701010060
Article History:
Received Date: 13/8/2007Revision Received Date: 3/10/2007
Acceptance Date: 3/10/2007
Electronic publication date: 26/10/2007
Collection year: 2007
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/) which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
We have characterized a broad range of liposome formulations with varying DcChol:DOPE ratio. Subsequent addition of DcChol to liposomes increases its positive surface charge. However, loading the nuclear acids did not neutralize the overall negative surface potential to a similar extent. The liposomes were tested by transfection of DNA in living cancer cells.