RESEARCH ARTICLE
Clinical Application of Computer-Aided Diagnostic System for Harmonious Introduction of Complementary Dialysis Therapy
Abdullah Al Mamun1, Hiroyuki Hamada*, 2, Tomokazu Karino3, Shinji Namoto3, Akihiro C Yamashita4, Makoto Ishizaki5, Masahiro Okamoto2
Article Information
Identifiers and Pagination:
Year: 2008Volume: 2
First Page: 10
Last Page: 16
Publisher ID: TOBEJ-2-10
DOI: 10.2174/1874120700802010010
Article History:
Received Date: 3/1/2008Revision Received Date: 4/3/2008
Acceptance Date: 6/3/2008
Electronic publication date: 1/4/2008
Collection year: 2008
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/) which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
In chronic peritoneal dialysis (PD) therapy, peritoneal permeability is gradually enhanced over the duration of the therapeutic course, leading to a grave decline in the therapeutic efficiency. In recent years, a novel therapy (CD therapy), which integrates PD therapy with hemodialysis therapy, is being applied to end-stage PD patients to complement the decline of therapeutic efficiency caused by the grave degeneration of the peritoneal tissue. To realize a harmonious introduction of the CD therapy, this study developed a useful index (KAu/c), which evaluates both therapeutic efficiency and degeneration of peritoneal tissue. Using a mathematical model and KAu/c, we were able to validate the therapeutic efficiency in the PD patients, and, in one case, propose a better prescription for the patient by employing the CD therapy. The clinical implementation of this methodology is indispensable with regard to expanding the therapeutic monitoring system for renal replacement therapy.
