The Open Biomedical Engineering Journal

ISSN: 1874-1207 ― Volume 10, 2016

Smart Sensors and Virtual Physiology Human Approach as a Basis of Personalized Therapies in Diabetes Mellitus

Carlos M Fernández Peruchena#, Manuel Prado-Velasco*, #
Multilevel Modelling and Emerging Technologies in Bioengineering (M2TB) Research Group, University of Seville, Spain


Diabetes mellitus (DM) has a growing incidence and prevalence in modern societies, pushed by the aging and change of life styles. Despite the huge resources dedicated to improve their quality of life, mortality and morbidity rates, these are still very poor. In this work, DM pathology is revised from clinical and metabolic points of view, as well as mathematical models related to DM, with the aim of justifying an evolution of DM therapies towards the correction of the physiological metabolic loops involved. We analyze the reliability of mathematical models, under the perspective of virtual physiological human (VPH) initiatives, for generating and integrating customized knowledge about patients, which is needed for that evolution. Wearable smart sensors play a key role in this frame, as they provide patient’s information to the models.

A telehealthcare computational architecture based on distributed smart sensors (first processing layer) and personalized physiological mathematical models integrated in Human Physiological Images (HPI) computational components (second processing layer), is presented. This technology was designed for a renal disease telehealthcare in earlier works and promotes crossroads between smart sensors and the VPH initiative. We suggest that it is able to support a truly personalized, preventive, and predictive healthcare model for the delivery of evolved DM therapies.

Keywords:: Diabetes mellitus, personalized therapies, metabolic syndrome, multilevel physiological modeling, virtual physiological human, digital healthcare, EHR..

Article Information

Identifiers and Pagination:

Year: 2010
Volume: 4
First Page: 236
Last Page: 249
Publisher Id: TOBEJ-4-236
DOI: 10.2174/1874120701004010236

Article History:

Received Date: 17/3/2010
Revision Received Date: 24/7/2010
Acceptance Date: 28/7/2010
Electronic publication date: 8/8/2010
Collection year: 2010

© Peruchena and Prado-Velasco; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Multilevel Modelling and Emerging Technologies in Bioengineering (M2TB), Research Group, Departamento de Ingeniería Gráfica, Escuela Superior de Ingenieros, Universidad de Sevilla, C. de los Descubrimientos, s/n , 41092 – Sevilla, Spain; Tel: 034 954486160; Fax: 034 954486158; E-mail: Authors contributed equally to this work.


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