The Open Biomedical Engineering Journal

ISSN: 1874-1207 ― Volume 13, 2019

Hybrid Matrix Grafts to Favor Tissue Regeneration in Rabbit Femur Bone Lesions

Dante Pascual Goy a, Emmanuel Gorosito a, Hermes S Costa b, Pablo Mortarino a, Noelia Acosta Pedemonte a, Javier Toledo a, Herman S Mansur b, Marivalda M Pereira b, *, Ricardo Battaglino c, Sara Feldman a
a LABOATEM: Fac Cs Médicas, Universidad Nacional de Rosario, Argentina
b Dep. Eng. Metalúrgica e de Materiais, Universidade Federal de Minas Gerais, Brasil
c Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA


At present, typical approaches employed to repair fractures and other bone lesions tend to use matrix grafts to promote tissue regeneration. These grafts act as templates, which promote cellular adhesion, growth and proliferation, osteoconduction, and even osteoinduction, which commonly results in de novo osteogenesis. The present work aimed to study the bone-repairing ability of hybrid matrixes (HM) prepared with polyvinyl alcohol (PVA) and bioactive glass in an experimental rabbit model. The HM were prepared by combining 30% bioactive glass (nominal composition of 58% SiO2 -33 % CaO - 9% P2O5) and 70% PVA. New Zealand rabbits were randomly divided into the control group (C group) and two groups with bone lesions, in which one received a matrix implant HM (Implant group), while the other did not (no Implant group). Clinical monitoring showed no altered parameters from either the Implant or the no Implant groups as compared to the control group, for the variables of diet grades, day and night temperatures and hemograms. In the Implant group, radiologic and tomographic studies showed implanted areas with clean edges in femoral non-articular direction, and radio-dense images that suggest incipient integration. Minimum signs of phlogosis could be observed, whereas no signs of rejection at this imaging level could be identified. Histological analysis showed evidence of osteo-integration, with the formation of a trabecular bone within the implant. Together, these results show that implants of hybrid matrixes of bioactive glass are capable of promoting bone regeneration.

Keywords: Bone regeneration, hybrid matrix, bioactive glass, polyvinyl alcohol, femur bone lesion..

Article Information

Identifiers and Pagination:

Year: 2012
Volume: 6
First Page: 85
Last Page: 91
Publisher Id: TOBEJ-6-85
DOI: 10.2174/1874120701206010085

Article History:

Received Date: 8/3/2012
Revision Received Date: 15/5/2012
Acceptance Date: 29/5/2012
Electronic publication date: 10/7/2012
Collection year: 2012

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© Goy et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Universidade Federal de Minas Gerais Departamento de Eng. Metalúrgica e de Materiais Escola de Engenharia - Bloco 2 - Sala 3640 Av. Antônio Carlos, 6627-Pampulha 31.270-901 - Belo Horizonte – MG Brasil; Tel: (31) 3409-1845; Fax: (31) 3409-1810; E-mail:


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