The Open Biomedical Engineering Journal

ISSN: 1874-1207 ― Volume 13, 2019

Use of an Injectable Complex of β-Tricalcium Phosphate Granules, Hyaluronate, and Fibroblast Growth Factor-2 on Repair of Unstable Intertrochanteric Fractures

T Tanaka*, S Kitasato, M Chazono, Y Kumagae, T Iida, M Mitsuhashi, A Kakuta, K Marumo
Department of Orthopaedic Surgery NHO, Utsunomiya National Hospital, 2160, Shimo-Okamoto, Utsunomiya City 329-1193 Tochigi, Japan


We evaluated effects of an injectable complex of β-tricalcium phosphate (β-TCP) granules, hyaluronate, and recombinant human fibroblast growth factor-2 (rhFGF-2) on repair of unstable intertrochanteric fractures in elderly patients. Twenty-five patients (range, 76-91 years) having 31.A2 fractures (AO classification) were treated with injection of the complex followed by intramedullary nails. Bone regeneration and β-TCP resorption, unions of intertrochanteric fractures and displaced lesser trochanters to the shaft, and varus deformity of the femoral neck were assessed by X-ray and CT scans. Fracture union occurred in all cases and union of the displaced lesser trochanter to the shaft was obtained in 24 cases by 12 weeks. It is of interest that β-TCP granules were completely replaced by bone and marked new bone formation around the lesser trochanter was observed in all cases compared to cases not treated with the complex. This complex is a paste-like material that is easy to handle, and it may be of considerable use in treatment of both unstable intertrochanteric fractures and other cortical bone defects with minimal surgical invasion.

Keywords: : Hyaluronate, TCP intertrochanteric, fractures FGF-2, bone formation, bone union..

Article Information

Identifiers and Pagination:

Year: 2012
Volume: 6
First Page: 98
Last Page: 103
Publisher Id: TOBEJ-6-98
DOI: 10.2174/1874120701206010098

Article History:

Received Date: 23/5/2012
Revision Received Date: 14/8/2012
Acceptance Date: 15/8/2012
Electronic publication date: 15/10/2012
Collection year: 2012

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© Tanaka et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Orthopaedic Surgery NHO Utsunomiya National Hospital, 2160 Shimo-Okamoto, Utsunomiya city 329-1193 Tochigi Japan; Tel: +81 28 673 2111; Fax: +81 28 673 9117; E-mail:


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