The Open Biochemistry Journal




ISSN: 1874-091X ― Volume 12, 2018
REVIEW ARTICLE

Testosterone Retention Mechanism in Sertoli Cells: A Biochemical Perspective



Manjeet Kaur Gill-Sharma*
Neuroendocrinology Department (retired), National Institute for Research in Reproductive Health (ICMR), J. M. Street, Parel, Mumbai, 400012, India

Abstract

Mechanism(s) involved in regulating Intratesticular Testosterone levels (iT) have assumed importance in recent years, from the point of view of hormonal contraception. Contraceptives using Testosterone (T) in combination with Progestins (P), for more effective suppression of pituitary gonadotropins thereby iT, are not 100% effective in suppressing spermatogenesis in human males, likely due to pesrsistence of Intratesticular Dihydrotestosterone (iD) in poor-responders. Several lacunae pertaining to the mechanism of action of principal male hormone T during spermatogenesis remain to be resolved. Notably, the mechanism through which T brings about the stage-specific differentiation of germ cells lacking Androgen Receptors (AR). Testosterone is a highly anabolic steroid with a rapid tissue clearance rate. T is intratesticular substrate for synthesis of Dihydrotestosterone (DHT) and Estradiol (E2) involved in spermtaogenesis. Therefore, it is important to delineate the mechanism(s) for retention of iT, in order to understand regulation of its bioavailability in testis. In depth studies, pertaining to the role of androgen-binding protein(s) in sequestration, retention and bioavailability of T/DHT are required to understand male fertility regulation. The appropriate approach to overcome this lacuna would be development of mice lacking functional testicular Androgen-Binding Protein (ABPKO), but not deficient T/DHT, Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH), in order to understand its physiological functions. Insights gained about androgen retention mechanism(s) from the ABPKO murine model will be of immense help in improving the efficacy of male hormonal contraceptives and infertility management.

Keywords: Testosterone, Androgen-binding protein, Sex hormone-binding globulin, Megalin, Sertoli cell, Spermatogenesis.


Article Information


Identifiers and Pagination:

Year: 2018
Volume: 12
First Page: 103
Last Page: 112
Publisher Id: TOBIOCJ-12-103
DOI: 10.2174/1874091X01812010103

Article History:

Received Date: 15/03/2018
Revision Received Date: 12/06/2018
Acceptance Date: 13/06/2018
Electronic publication date: 29/06/2018
Collection year: 2018

Article Metrics:

CrossRef Citations:
0

Total Statistics:

Full-Text HTML Views: 809
Abstract HTML Views: 465
PDF Downloads: 509
ePub Downloads: 410
Total Views/Downloads: 2193

Unique Statistics:

Full-Text HTML Views: 417
Abstract HTML Views: 235
PDF Downloads: 226
ePub Downloads: 134
Total Views/Downloads: 1012
Geographical View

© 2018 Manjeet Kaur Gill-Sharma.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


* Address correspondence to this author at the A-602, Winchester Apt, 2nd Cross Lane, Lokhandwala Complex, Andheri (W), Mumbai-400053, India, Tel: 9819 307 305; Email: manjitgill_sharma@rediffmail.com


Endorsements



"We have always had a fruitful cooperation and long-term experience of publishing with Bentham Open."

"A number of our original papers have appeared in its different journals, as the Bentham Open Publishers provides sufficient research in the field of science and technologies (belonging to the pharmaceutical, biotechnology, biomedical industries etc). The staff of the Bentham Open always treat our papers very seriously and gently during the rutile paper reviewing process, so far we always felt their kindness and highly cooperative support. Today, Bentham Open is providing a great support to science and research, giving opportunities of high standard publishing as well as promoting and enhancing selected papers around the world through communication and exchange of global scientific education."


Kholmirzo T. Kholmurodov
Leading Scientist
FLNP (Frank Laboratory of Neutron Physics) JINR (Joint Institute of Nuclear Research) Moscow region, Russia


Browse Contents



Advertisements


Webmaster Contact: info@benthamopen.com
Copyright © 2018 Bentham Open