Vitamin D and Multiple Sclerosis: An Open-Ended Story
Concetta Scazzone1, *, Luisa Agnello1, *, Bruna Lo Sasso1, Anna Maria Ciaccio2, Rosaria V Giglio1, Giulia Bivona1, #, Marcello Ciaccio1, 3, #*
1 Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory Medicine, University of Palermo, Palermo, Italy
2 University of Palermo, Palermo, Italy
3 Department of Laboratory Medicine, University of Palermo, Palermo, Italy
Multiple Sclerosis (MS) is a chronic inflammatory autoimmune disease of the Central Nervous System (CNS). Genetic, epigenetic and environmental factors interact together, contributing to the complex pathogenesis of the disease. In the last decades, the role of hypovitaminosis D on MS risk was hypothesised. Several factors drive the regulation of vitamin D status, including genetics. The current review summarises the literature evidence on the association between vitamin D and MS, with a focus on the genetic polymorphisms in vitamin D-related genes. The variants of the genes codifying Vitamin D Receptor (VDR), Vitamin D Binding Protein (VDBP) and CYP enzymes have been investigated, but the findings are controversial. Only a few studies have addressed the role of DHCR7 polymorphisms in MS risk.
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
* Address correspondence to this author at Department of Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory Medicine, University of Palermo, Italy, Via del Vespro, 129, CAP 90127, Palermo, Sicily, Italy; Tel: 0039 09123865707 Email: email@example.com *Concetta Scazzone and Luisa Agnello are both considered first authors #Giulia Bivona and Marcello Ciaccio are both considered last authors.