The Open Biochemistry Journal


ISSN: 1874-091X ― Volume 11, 2017

Consensus Prediction of Protein Conformational Disorder from Amino Acidic Sequence



Suresh Kumar1, Oliviero Carugo*, 1, 2
1 Department of Biomolecular Structural Chemistry, Max F. Perutz Laboratories, Vienna University, Campus Vienna Biocenter 5, A-1030 Vienna, Austria
2 Department of General Chemistry, Pavia University, Viale Taramelli 12, I-27100 Pavia, Italy

Abstract

Predictions of protein conformational disorder are important in structural biology since they can allow the elimination of protein constructs, the three-dimensional structure of which cannot be determined since they are natively unfolded. Here a new procedure is presented that allows one to predict with high accuracy disordered residues on the basis of protein sequences. It makes use of twelve prediction methods and merges their results by using least-squares optimization. A statistical survey of the Protein Data Bank is also reported, in order to know how many residues can be disordered in proteins that were crystallized and the three-dimensional structure of which was determined.



Article Information


Identifiers and Pagination:

Year: 2008
Volume: 2
First Page: 1
Last Page: 5
Publisher Id: TOBIOCJ-2-1
DOI: 10.2174/1874091X00802010001

Article History:

Received Date: 12/11/2007
Revision Received Date: 26/11/2007
Acceptance Date: 12/12/2007
Electronic publication date: 18/1/2008
Collection year: 2008

2008 Bentham Science Publishers Ltd.


* Address correspondence to this author at the Department of Biomolecular Structural Chemistry, Max F. Perutz Laboratories, Vienna University, Campus Vienna Biocenter 5, A-1030 Vienna, Austria E-mail: oliviero.carugo@univie.ac.at


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