The Open Biochemistry Journal




ISSN: 1874-091X ― Volume 13, 2019

Subunit Mobility and the Chaperone Activity of Recombinant αB-Crystallin



A Krushelnitsky*, 1, N Mukhametshina1, Y Gogolev1, N Tarasova1, D Faizullin1, T Zinkevich2, O Gnezdilov2, V Fedotov1
1 Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, Kazan, Russia
2 Kazan Physical-Technical Institute, Russian Academy of Sciences, Kazan, Russia

Abstract

The comparison of the chaperone-like activity of native and covalently cross-linked human αB-crystallins has confirmed the important role of the subunit mobility in the chaperoning mechanism. Our data clearly demonstrate that the chaperone-like activity of α-crystallin is not only a surface phenomenon as was suggested by some researchers.



Article Information


Identifiers and Pagination:

Year: 2008
Volume: 2
First Page: 116
Last Page: 120
Publisher Id: TOBIOCJ-2-116
DOI: 10.2174/1874091X00802010116

Article History:

Received Date: 31/7/2008
Revision Received Date: 5/8/2008
Acceptance Date: 6/8/2008
Electronic publication date: 2/9/2008
Collection year: 2008

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© Krushelnitsky et al; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http: //creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.


* the Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, Kazan, Russia;E-mail: krushelnitsky@mail.knc.ru


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