The Open Biochemistry Journal




ISSN: 1874-091X ― Volume 12, 2018

Effects of Red Grape Juice Consumption on High Density Lipoprotein-Cholesterol, Apolipoprotein AI, Apolipoprotein B and Homocysteine in Healthy Human Volunteers



Mohammad H Khadem-Ansari*, Yousef Rasmi, Fatemeh Ramezani
Department of Clinical Biochemistry and Nutrition, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Abstract

It has suggested that grape juice consumption has lipid- lowering effect and it is associated with a decreased risk of heart disease. We aimed to evaluate the effects of red grape juice (RGj) consumption on high density lipoprotein-cholesterol (HDL-C), apolipoprotein AI (apoAI), apolipoprotein B (apoB) and homocysteine (Hcy) levels in healthy human volunteers. Twenty six healthy and nonsmoking males, aged between 25-60 years, who were under no medication asked to consume 150 ml of RGj twice per day for one month. Serum HDL-C, apoAI, apoB and plasma Hcy levels were measured before and after one month RGj consumption. HDL-C levels after RGj consumption were significantly higher than the corresponding levels before the RGj consumption (41.44 ± 4.50 and 44.37 ± 4.30 mg/dl; P<0.0001). Also, apoB was significantly increased after RGj consumption (149.0 ± 22.35 and 157.19 ± 18.60 mg/dl; P<0.002). But apoAI levels were not changed significantly before and after of RGj consumption (154.27 ± 21.55 and 155.35 ± 21.07 mg/dl; P>0.05). Hcy levels were decreased after RGj consumption (7.70 ± 2.80 and 6.20 ± 2.30 µmol/l; P<0.001). The present study demonstrates that RGj consumption can significantly increase serum HDL-C levels and decrease Hcy levels. These findings may have important implications for the prevention of atherosclerosis in healthy individuals.

Keywords: Red grape, lipids, lipoproteins, homocystein, athersclerosis.


Article Information


Identifiers and Pagination:

Year: 2010
Volume: 4
First Page: 96
Last Page: 99
Publisher Id: TOBIOCJ-4-96
DOI: 10.2174/1874091X01004010096

Article History:

Received Date: 20/03/2010
Revision Received Date: 28/06/2010
Acceptance Date: 10/07/2010
Electronic publication date: 15/12/2010
Collection year: 2010

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© Khadem-Ansari et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http: //creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.


* Address correspondence to this author at the Department of Clinical Biochemistry and Nutrition, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran; Tel: +98-9141415879; Fax: +98-441-2780801; E-mail: mhansari1@hotmail.com


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