Compared to ion pumps and carriers, ion channels have been quite late recognised as individual transport
identities in red blood cells. Here the transition from cell population based flux experiments to single cell based patchclamp
investigations are described in detail. The present knowledge of cation channels in red blood cells from their
molecular identity to their electrophysiological properties are summarised. Tendencies and novel concepts for future
research concerning ion-transport across the red blood cell membrane are discussed.