RESEARCH ARTICLE
Relationship between Uric Acid Levels and Diagnostic and Prognostic Outcomes in Acute Heart Failure
Queen Henry-Okafor1, Sean P. Collins2, Cathy A. Jenkins1, Karen F. Miller1, David J. Maron1, Allen J. Naftilan1, Neal Weintraub3, Gregory J. Fermann2, John McPherson1, Santosh Menon4, Douglas B. Sawyer1, Alan B. Storrow1, *
Article Information
Identifiers and Pagination:
Year: 2012Volume: 5
First Page: 9
Last Page: 15
Publisher ID: TOBIOMJ-5-9
DOI: 10.2174/1875318301205010009
Article History:
Received Date: 28/02/2012Revision Received Date: 25/04/2012
Acceptance Date: 30/04/2012
Electronic publication date: 13/7/2012
Collection year: 2012
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Objectives:
We evaluated the association of plasma uric acid alone and in combination with b-type natriuretic peptide (BNP) for emergency department (ED) diagnosis and 30-day prognosis in patients evaluated for acute heart failure (AHF).
Methods:
We prospectively enrolled 322 adult ED patients with suspected AHF. Wilcoxon rank sum test, multivariable logistic regression and likelihood ratio (LR) tests were used for statistical analyses.
Results:
Uric acid's diagnostic utility was poor and failed to show significant associations with 30-day clinical outcomes. Uric acid also did not add significantly to BNP results.
Conclusion:
Among ED patients with suspected AHF, uric acid has poor diagnostic and prognostic utility