Urinary Biomarkers of Oxidative Stress in Atrial Fibrillation
Lei Mengǂ1, Ricko Wongǂ2, Man Yin Tsui3, Gary Tse4, 5, Guangping Li1, Tong Liu*, 1, Gregory Y. H. Lip6
1 Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin300211, P.R. China
2 Faculty of Medicine, The University of Notre Dame, Perth, Australia
3 Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, SAR, P.R. China
4 Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, SAR, P.R. China
5 Li Ka Shing Institute of Health Sciences, 30-32 Ngan Shing St, Chinese University of Hong Kong, Hong Kong, SAR, P.R. China
6 University of Birmingham Institute of Cardiovascular Sciences, City Hospital, BirminghamB18 7QH, United Kingdom
There is increasing evidence from molecular studies to support the role of inflammation and increased oxidative stress that produce structural and electrical atrial remodeling to produce Atrial Fbrillation (AF). Oxidative damage to cardiomyocytes yields chemical substances that are secreted in urine. These substances can serve as biomarkers that can be measured, potentially allowing clinicians to quantify oxidative damage to the heart.
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* Address correspondence to this author at the Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, People’s Republic of China, Tel: +86-22-88328368; Fax: +86-22-28261158. E-mail: firstname.lastname@example.orgǂThe first two authors contribute equally to this work.