RESEARCH ARTICLE


Gray Box Modeling of Supercritical Nimbin Extraction from Neem Seeds Using Methanol as Co-Solvent



G. Zahedi*, b, S. Azizia, T. Hatamia, L. Sheikhattara
a Simulation and Artificial Intelligence Research Center, Chemical Engineering Department, Razi University, Kermanshah, Iran
b Process Systems Engineering Centre (PROSPECT), Faculty of Chemical and Natural Resources Engineering, University Technology Malaysia, UTM Skudai, 81310 Johor Bahru, Johor, Malaysia


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Creative Commons License
© 2017 Zahedi et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Process Systems Engineering Centre (PROSPECT), Faculty of Chemical and Natural Resources Engineering, University Technology Malaysia, UTM Skudai, 81310 Johor Bahru, Johor, Malaysia; Fax: +(6)-07-5581463; E-mail: grzahedi@yahoo.com


Abstract

In this paper yield of nimbin extraction from neem seeds using supercritical carbon dioxide with methanol as co-solvent has been studied. In this case mass transfer coefficient in terms of Sherwood number has been estimated by a neuro-fuzzy network. Then the estimated mass transfer coefficient has been fed to the system model which is set of partial differential equations. The proposed gray box model was validated with experimental data.

Keywords: Orofacial pain, Nimbin, supercritical fluid extraction, neuro-fuzzy modeling, gray box.