Department of Cellular Pathology, Royal Free Hospital, London NW3 2QG, London, United Kingdom
Cardiovascular disease is a leading cause of death among patients with end stage renal failure. Animal models have played a crucial role in teasing apart the complex pathological processes involved. This review discusses the principles of using animal models, the history of their use in the study of renal hypertension, the controversies arising from experimental models of non-hypertensive uraemic cardiomyopathy and the lessons learned from these models, and highlights important areas of future research in this field, including de novo cardiomyopathy secondary to renal transplantation.
Keywords: Non-hypertensive uraemic, de novo cardiomyopathy, renal transplantation, karyotypes, isoform..
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