The Open Cardiovascular Medicine Journal

ISSN: 1874-1924 ― Volume 14, 2020

Pharmacokinetic Considerations for Digoxin in Older People

Geoffrey M Currie1, 2, 3, *, Janelle M Wheat1, 2, 3, Hosen Kiat1, 2, 3
1 Faculty of Science, Charles Sturt University, Wagga Wagga, Australia
2 Australian School of Advanced Medicine, Macquarie University, Cardiac Health Institute, Sydney, Australia
3 Centre for Research in Complex Systems, Charles Sturt University, Wagga Wagga, Australia



This review aims to arm readers with a deep understanding of pharmacokinetics of digoxin.

Data Sources:

Pharmacology and pharmacokinetic references texts, and peer reviewed medical journal manuscripts indexed on Medline included based on currency, accuracy and appropriateness.


Results: Physiologic changes and disease associated with aging have an impact on pharmacokinetics and pharmacodynamics of medications. Altered drug response and increased adverse reactions are common amongst the elderly. The narrow therapeutic index of digoxin and pharmacokinetic changes associated with aging increases the risk of toxicity. In the aging population, a number of factors combine to increase the risk, severity and likelihood of hospitalisation or death due to adverse drug effects:

  • changes to absorption, distribution, metabolism and excretion,
  • increased susceptibility to drug sensitivity,
  • co-existing pathology,
  • polypharmacy.


A thorough understanding of digoxin pharmacokinetics in the older person is essential for improved therapeutic outcomes, improved compliance, reduced morbidity and improved quality of life.

Keywords: Ageing, digoxin, pharmacokinetics, toxicity..

Article Information

Identifiers and Pagination:

Year: 2011
Volume: 5
First Page: 130
Last Page: 135
Publisher Id: TOCMJ-5-130
DOI: 10.2174/1874192401105010130

Article History:

Received Date: 8/4/2011
Revision Received Date: 29/4/2011
Acceptance Date: 30/4/2011
Electronic publication date: 15/6/2011
Collection year: 2011

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© Currie et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Faculty of Science, Locked Bag 588, Charles Sturt University, Wagga Wagga 2678, Australia; Tel: 61 2 69332822; E-mail:


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