The Open Dentistry Journal




ISSN: 1874-2106 ― Volume 13, 2019
CASE REPORT

Malignant Transformation of Ossifying Fibroma into Parosteal Osteosarcoma with High-grade Component: Presentation of an Unusual Case and Review of the Literature



Jahan Abtahi1, 2, *, Aida Ajan1
1 Department of Oral and Maxillofacial Surgery, Linköping University Hospital, Linköping, Sweden
2 Department of Otolaryngology, Head and Neck Oncology, Linköping University Hospital, Linköping, Sweden

Abstract

Background:

Parosteal Osteosarcoma of the Jaw (POSJ) is a rare entity that is associated with a high survival rate. Several case reports and case series of POSJ have been published in the literature, but few authors have described development of this tumor by possible transformation from a fibro-osseous neoplasm.

Objective:

We present a rare occurrence of parosteal osteosarcoma with involvement of the posterior maxilla, orbit floor, and infra-temporal fossa in a 20-year-old man. Furthermore, we performed a literature review regarding clinical, radiological, and histological features; treatment strategies; and etiology/pathophysiology.

Methods:

A PubMed search yielded a total of 74 articles and the articles were sorted according to their corresponding key area of focus.

Results:

This was a case of POSJ with high-grade component in the maxillofacial region of a 20-year old male. Co-expression of MDM2 and CDK4 was confirmed. At 2.5-year follow-up, the patient had died. The literature review revealed 18 articles including 20 cases of POSJ. Four cases represent the possible development of this tumor by transformation from a fibro-osseous neoplasm: Two cases of fibrous dysplasia, one case of cemento-ossifying fibroma, and the case of Ossifying Fibroma (OF) in the present study.

Conclusion:

In conclusion, we found an unusual case of POSJ of the midface in a patient with a previous diagnosis of OF in the same region. To our knowledge, there have been no previous reports of development of POSJ in OF. Furthermore, this is the first described case of high-grade surface osteosarcoma in the craniofacial region.

Keywords: Facial bone, Jaw, Malignant tumor, Neoplasm, Osteosarcoma, Parosteal.


Article Information


Identifiers and Pagination:

Year: 2018
Volume: 12
First Page: 1059
Last Page: 1068
Publisher Id: TODENTJ-12-1059
DOI: 10.2174/1874210601812011059

Article History:

Received Date: 27/7/2018
Revision Received Date: 16/10/2018
Acceptance Date: 14/11/2018
Electronic publication date: 30/11/2018
Collection year: 2018

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© 2018 Abtahi and Ajan.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


* Address Correspondence to this author at Department of Oral and Maxillofacial Surgery, Linköping University Hospital, SE-581 85 Linköping, Sweden/ Department of Otolaryngology, Head and Neck Oncology, Linköping University Hospital, SE-581 85 Linköping, Sweden; Tel: +46 (0)70 756 69 97; E-mails: jahan.linkoping@gmail.com, jahan.abtahi@regionostergotland.se


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