The Open Dentistry Journal

ISSN: 1874-2106 ― Volume 13, 2019

Effectiveness of Platelet Rich Plasma and Bone Graft in the Treatment of Intrabony Defects: A Clinico-radiographic Study

Mohammad Jalaluddin1, *, Jayachandran Mahesh2, Rethi Mahesh3, Ipsita Jayanti1, Mohamed Faizuddin4, Krishna Kripal5, Nazia Nazeer6
1 Department of Periodontics & Oral Implantology, Kalinga Institute of Dental Sciences, KIIT University, Bhubaneswar, Odisha, India
2 Department of Periodontics, Noorul Islam College of Dental Sciences, Thiruvananthapuram, Kerala, India
3 Department of Endodontics & Conservative Dentistry, Noorul Islam College of Dental Sciences, Thiruvananthapuram, Kerala, India
4 Department of Periodontology and Oral Implantology, R.V.Dental College and Hospital, Bengaluru, Karnataka, India
5 Department of Periodontology & Oral Implantology, Raja Rajeswari Dental College & Hospital, Bengaluru, Karnataka, India
6 Kalinga Institute of Dental Sciences, KIIT University, Bhubaneswar, Odisha, India


Background & Objectives:

Periodontal disease is characterized by the presence of gingival inflammation, periodontal pocket formation, loss of connective tissue attachment and alveolar bone around the affected tooth. Different modalities have been employed in the treatment and regeneration of periodontal defects which include the use of bone grafts, PRP and other growth factors.The purpose of this prospective, randomized controlled study was to compare the regenerative efficacy of PRP and bonegraft in intrabony periodontal defects.


This randomized control trial was carried out in the Department of Periodontics & Oral Implantology, Kalinga Institute of Dental Sciences and Hospital, KIIT University, Bhubaneswar. The study sample included 20 periodontal infrabony defects in 20 patients, 12 males and 8 females. The patients were aged between 25 -45 years(with mean age of 35 years). The 20 sites selected for the study were was randomly divided into 2 groups of 10 sites each. Group A: PRP alone, Group B: Bone Graft.

Statistical Anaysis & Results: Statistical Analysis Was Done Using SPSS (Version 18.0):

Statistical analysis was done usingpaired ‘t’ tests and ANOVA that revealed a significant reduction ingingival index, plaque index, probing pocket depth and gain in clinical attachment level at various time intervalswithin both the groups. Radiographic evaluation revealed statistically significant defect fill (p<0.001) at the end of 6months within both the groups. However, there was astatistically significant difference seen in group B radiographically, when compared to group A.


Both the groups showed promising results in enhancing periodontal regeneration; however the resultswith bonegraftwere comparatively better, although not statistically significant when compared to PRP alone.

Keywords: Bone graft, Infrabony defects, Periodontal regeneration, PRP. Platelet Derived growth factors (PDGF), Epithelial growth factor (EGF).

Article Information

Identifiers and Pagination:

Year: 2018
Volume: 12
First Page: 133
Last Page: 154
Publisher Id: TODENTJ-12-133
DOI: 10.2174/1874210601812010133

Article History:

Received Date: 17/11/2017
Revision Received Date: 30/11/2017
Acceptance Date: 5/12/2017
Electronic publication date: 12/02/2018
Collection year: 2018

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© 2018 Jalaluddin et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this authors at the Department of Periodontics & Oral Implantology, Kalinga Institute of Dental Sciences, KIIT University, Bhubaneswar, Odisha, India, Tel: 9338131843; E-mail:


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