The Open Dentistry Journal

ISSN: 1874-2106 ― Volume 13, 2019

Recurrent Oral Eosinophilic Ulcers of the Oral Mucosa. A Case Report

Norberto Sugaya, Fernanda Martignago, Decio Pinto, Dante Migliari*
Department of Stomatology, Oral Medicine Division, School of Dentistry, University of São Paulo, São Paulo, SP. Brazil



This article describes a case of an Oral Eosinophilic Ulcer (OEU) in an otherwise healthy 31-year-old white woman.


The importance of reporting this case was the presence of recurrent episodes with lesions appearing in different areas of the oral mucosa, a type of manifestation not commonly associated with this disease. A typical manifestation of OEU occurs as a single ulceration that goes into healing after an incisional biopsy, a procedure usually required for a proper diagnosis of the disease. In spite of trauma being suggested as the main culprit of OEU, the exact pathogenesis mechanism of this disease remains controversial.

Case report:

The pattern of the present case contradicts the usually common course of the disease, as the patient had experienced many recurrent episodes for almost 2.5 years, with the recurrences occurring even after biopsies performed during some of the relapses. Differential diagnosis included recurrent aphthous stomatitis, recurrent intra-oral herpes, autoimmune disease, Crohn’s disease and malignancy.


Fortunately, the patient has been free of any recurrences for 1.5 years since the last biopsy was taken at the time she came to our clinic seeking treatment.

Keywords: Oral ulcerations, Diagnosis, Eosinophilic ulcer, Recurrences, Crohn’s disease, Oral mucosa.

Article Information

Identifiers and Pagination:

Year: 2018
Volume: 12
First Page: 19
Last Page: 23
Publisher Id: TODENTJ-12-19
DOI: 10.2174/1874210601812010019

Article History:

Received Date: 09/09/2017
Revision Received Date: 26/12/2017
Acceptance Date: 01/01/2018
Electronic publication date: 29/1/2018
Collection year: 2018

Article Metrics:

CrossRef Citations:

Total Statistics:

Full-Text HTML Views: 3859
Abstract HTML Views: 1836
PDF Downloads: 1387
ePub Downloads: 960
Total Views/Downloads: 8042

Unique Statistics:

Full-Text HTML Views: 1819
Abstract HTML Views: 859
PDF Downloads: 440
ePub Downloads: 334
Total Views/Downloads: 3452
Geographical View

© 2018 Sugaya et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondenceto this author at the University of Sao Paulo, School of Dentistry Av, Prof, Lineu Prestes, 2227, São Paulo, SP- Brazil, Tel: (+55 11 94383-7972); E-mail:


"Thank you for your magnificent and marvelous support throughout the publication stages. I would like to endorse my experience with you as a Junior Researcher and a recent graduate of the Dental school. Once again Thank you for your Great Help and Guidance throughout the stages of Publication. You guys are a great team and I am proud to be a Young Bentham author."

Asra Sabir Hussain
The University of Edinburgh Business School, UK

"My experience with Bentham Open was a valuable one because the quality of the services and analysis of my paper contributed in improving what we intended to convey to the readers."

José Ricardo Kina
Department of Surgery and Integrated Clinic,
Araçatuba School of Dentistry, São Paulo State University

"The Publication Manager was very cooperative and replied my mails and guided me without any delays; however the reviewing process was too long."

Mahtab Memarpour
Prevention of Oral and Dental Disease Research Center,
Department of Pediatric Dentistry, School of Dentistry,
Shiraz University of Medical Sciences, Shiraz,

Browse Contents

Webmaster Contact:
Copyright © 2019 Bentham Open