The Open Dentistry Journal




ISSN: 1874-2106 ― Volume 13, 2019
CASE REPORT

Long-Term Effects of Acute Myeloid Leukemia Treatment on the Oral System in a Pediatric Patient



Saturnino Marco Lupi1, *, Arianna Rodriguez y Baena1, Gabriele Cervino2, Claudia Todaro1, Silvana Rizzo1
1 Department of Clinical, Surgical, Pediatric and Diagnostic Sciences, School of Dentistry, University of Pavia, P.le Golgi 2, 27100 Pavia, Italy
2 Department of Biomedical and Dental Sciences, Morphological and Functional Images, School of Dentistry, University of Messina, Policlinico G. Martino, Via Consolare Valeria, 98100 Messina, Italy

Abstract

Introduction:

Acute Myeloid Leukemia (AML) in pediatric patients is a serious disease, although, for the subgroup of patients who receive proper treatment, a long-term survival rate above 50% is typical. The cycles of chemo- and radiotherapy used to treat AML can impair dental development.

Case Report:

Herein, we describe the oral condition of a 25-year-old male patient treated for AML with chemo- and radiotherapy from 5 to 7 years of age; his AML has remained in remission for the past 18 years. He had lost only one permanent tooth, but the remaining teeth demonstrated serious deformations and radicular hypoplasia. Two teeth required immediate extraction and subsequent replacement by implant-supported crowns. We found that the decayed, missing, filled teeth (DMFT) index was not representative of the real oral condition. Here, we report the full case and provide a brief review of the literature.

Conclusion:

Antitumor treatment of pediatric leukemia can induce total impairment of dental development and function. These adverse effects may become clinically evident many years after the resolution of cancer, and can be significantly detrimental to the patient’s quality of life.

Keywords: Acute myeloid leukemia, Dental anomalies, Children teeth, Bone marrow transplantation, Long-term effects, Dental implants.


Article Information


Identifiers and Pagination:

Year: 2018
Volume: 12
First Page: 230
Last Page: 237
Publisher Id: TODENTJ-12-230
DOI: 10.2174/1874210601812010230

Article History:

Received Date: 25/12/2017
Revision Received Date: 20/02/2018
Acceptance Date: 28/02/2018
Electronic publication date: 30/03/2018
Collection year: 2018

Article Metrics:

CrossRef Citations:
0

Total Statistics:

Full-Text HTML Views: 2169
Abstract HTML Views: 1566
PDF Downloads: 488
ePub Downloads: 843
Total Views/Downloads: 5066

Unique Statistics:

Full-Text HTML Views: 1211
Abstract HTML Views: 775
PDF Downloads: 341
ePub Downloads: 270
Total Views/Downloads: 2597
Geographical View

© 2018 Lupi et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


* Address correspondence to this author at the Department of Clinical, Surgical, Pediatric and Diagnostic Sciences, School of Dentistry, University of Pavia, Saturnino Marco Lupi, P.le Golgi 2, 27100 Pavia, Italy; Tel: +39 382516255; E-mail: saturninomarco.lupi@unipv.it


Endorsements



"Thank you for your magnificent and marvelous support throughout the publication stages. I would like to endorse my experience with you as a Junior Researcher and a recent graduate of the Dental school. Once again Thank you for your Great Help and Guidance throughout the stages of Publication. You guys are a great team and I am proud to be a Young Bentham author."


Asra Sabir Hussain
The University of Edinburgh Business School, UK

"My experience with Bentham Open was a valuable one because the quality of the services and analysis of my paper contributed in improving what we intended to convey to the readers."


José Ricardo Kina
Department of Surgery and Integrated Clinic,
Araçatuba School of Dentistry, São Paulo State University
Brazil

"The Publication Manager was very cooperative and replied my mails and guided me without any delays; however the reviewing process was too long."


Mahtab Memarpour
Prevention of Oral and Dental Disease Research Center,
Department of Pediatric Dentistry, School of Dentistry,
Shiraz University of Medical Sciences, Shiraz,
Iran


Browse Contents



Webmaster Contact: info@benthamopen.net
Copyright © 2019 Bentham Open