The Open Dentistry Journal

ISSN: 1874-2106 ― Volume 14, 2020

Clinical Efficacy in Relieving Dentin Hypersensitivity of Nanohydroxyapatite-containing Cream: A Randomized Controlled Trial

Bennett T. Amaechi1, *, Kelly C. Lemke2, Shyamali Saha1, Jonathan Gelfond3
1 Department of Comprehensive Dentistry, University of Texas Health Science Center, San Antonio, Texas, USA
2 Department of Developmental Dentistry, University of Texas Health Science Center, San Antonio, Texas, USA
3 Department of Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio, Texas, USA



The study aimed to investigate the effectiveness of Apadent Pro (Sangi) Nanohydroxyapatite (nHAP) dental cream to relieve Dentin Hypersensitivity (DHS), compared with a positive control cream containing 20% pure silica (Silica).


In this double-blind, randomized, parallel-group clinical trial, patients diagnosed with DHS and qualified to participate were randomized into two groups, nHAP (n=25) and Silica (n=26). Subjects’ baseline and posttreatment sensitivity were assessed using two pain scales, a four-point Dental Pain Scale (DPS) followed by a linear Visual Analog Scale (VAS), after the application of ice-cold and air stimuli. Subjects used custom-fabricated trays to apply their respective cream for 5 minutes once daily following brushing with standard fluoride toothpaste. Posttreatment sensitivity (efficacy) was assessed every 2 weeks for 8 weeks. Mean treatment outcomes (percentage change from baseline) at each time point were compared using the Tukey HSD test for multiplicity (P<0.05).


With either air or cold stimulus, VAS and DPS indicated a significant (P<0.001) reduction in DHS at each time point with either nHAP or Silica. Comparing pain scales, VAS showed no significant difference in DHS reduction between the products with either air or cold. However, with DPS, DHS reduction was significantly (P<0.05) better with Silica than with nHAP at all time points with cold, and at 2, 4, and 8 weeks with air.


Both Apadent Pro nHAP and Silica dental creams are effective at promoting the relief of DHS symptoms. When comparing the efficacy of the two compounds to relieve DHS, results of the two pain scales were conflicting.

Keywords: Dentifrice, Dentin hypersensitivity, Dentin tubules, Nanohydroxyapatite, Silica, Tubule occlusion.

Article Information

Identifiers and Pagination:

Year: 2018
Volume: 12
First Page: 572
Last Page: 585
Publisher Id: TODENTJ-12-572
DOI: 10.2174/1874210601812010572

Article History:

Received Date: 23/5/2018
Revision Received Date: 11/7/2018
Acceptance Date: 10/8/2018
Electronic publication date: 31/08/2018
Collection year: 2018

© 2018 Amaechi et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to the author at the Department of Comprehensive Dentistry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA; Tel: +12105673187; Fax: +12105674587; E-mail:

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