The Open Dentistry Journal

ISSN: 1874-2106 ― Volume 13, 2019

Dental Implant Rehabilitation in Patients Suffering from Mucocutaneous Diseases: A Systematic Review and Meta-Analysis

Parichehr Zarean1, Paridokht Zarean2, Negar Kanounisabet3, *, Ahmad Moghareabed4, Mansour Rismanchian5, Ghasem Yadegarfar6
1 Dental research center, School of Dentistry, Isfahan University of Medical Science, Isfahan, Iran
2 Dental Implants Research Center, School of Dentistry, Isfahan University of Medical Science, Isfahan, Iran
3 Department of Periodontology, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
4 Dental Implants Research Center, Department of Periodontology, School of Dentistry, Isfahan University of Medical Science, Isfahan, Iran
5 Dental Implants Research Center, Department of Prosthodontics, School of Dentistry, Isfahan University of Medical Science, Isfahan, Iran
6 Department of Epidemiology and Biostatics, School of Public Health, Isfahan University of Medical Science, Isfahan, Iran



Dental implantations are widely used for oral rehabilitation of edentulous patients. Despite high success rate, there are some risk factors that have been associated with failures. Oral mucocutaneous diseases are one of these risk factors for implant insertion due to the immunosuppressive therapy.

There are limited studies that have dealt with the subject of dental implantology in oral mucosal disorders mainly with patients with oral lichenplanus, pemphigoid, pemphigus vulgaris, and systemic lupus erythematosus. In order to assess the result of implantations in such patients, we have reviewed the studies.

Materials and Methods:

We searched PubMed, Science Direct, and Cochrane databases for articles published from Jan 2000 to Dec 2017, using key search word “dental implants”, “oral lichen planus”, “pemphigoid”, “pemphigus vulgaris” and ”systemic lupus erythematosus”.


The random effects analysis result shows overall failure rates of 22% in patients with oral lichen planus. A systematic review revealed some failures that are not definitely related to these diseases.


Due to the lack of adequate studies, a meta-analysis was only possible for oral lichen planus. Presently, there is no definite guideline regarding the placement of implant in patients suffering from mucocutaneous diseases; nevertheless, we should always consider that these patients are specific cases and need more attention in the first step of treatment and follow-ups. So there is a need to further clinical studies in order to evaluate more risk factors accurately and make a definitive conclusion.

Keywords: Dental Implants, Oral lichen planus, Pemphigoid, Pemphigus vulgaris, Systemic lupus erythematosus, Mucocutaneous diseases.

Article Information

Identifiers and Pagination:

Year: 2018
Volume: 12
First Page: 873
Last Page: 883
Publisher Id: TODENTJ-12-873
DOI: 10.2174/1874210601812010873

Article History:

Received Date: 18/6/2018
Revision Received Date: 30/8/2018
Acceptance Date: 2/10/2018
Electronic publication date: 30/10/2018
Collection year: 2018

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© 2018 Zarean et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address Correspondence to this author at the Department of Periodontology, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran; Tel: +983137925570; E-mail:


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