The Open Dentistry Journal

ISSN: 1874-2106 ― Volume 14, 2020

Clinical and Biochemical Evaluation of the Effect of Diode Laser Treatment Compared to the Non-surgical and Surgical Treatment of Periodontal Diseases

Mirlinda Sopi1, Ferit Koçani2, Merita Bardhoshi3, Kastriot Meqa4, *
1 Dentistry School,University of Pristina, Pristina, Kosovo
2 Department of Dental Pathology and Endodontics, University of Pristina Dentistry School, Pristina, Kosovo
3 Department of Oro-Maxillofacial Surgery, Medical University of Tirana, Tirana, Albania
4 Department of Periodontology and Oral Medicine, University of Pristina Dentistry School, Pristina, Kosovo



Periodontal therapy consists of eliminating the inflammation, treating periodontal pockets, motivating the patient for oral hygiene, and, if necessary, for surgical treatment. Recently, the application of a diode laser is widely being investigated for periodontal disease treatment.


The analysis and evaluation of the clinical and biochemical impact of diode laser periodontal treatment, compared to either surgical or non-surgical, therapy, was the aim of this study.


The study involved 80 patients older than 18 with at least 20 teeth. Evaluation of periodontal parameters was done conveniently on a single-rooted tooth (incisive, canine, premolar) on six surfaces, before the start of periodontal therapy, and after three, and six months. The laser used in the study was a diode laser with a wavelength of 980 nm. Digital X-rays were taken for bone level evaluation before and after the treatment. The presence of a bone destruction mediator (Matrix metalloproteinase-8 - MMP-8) was evaluated by the dipstick immunoassay test. Biochemical analysis and radiographic measurements were evaluated at the baseline and six months after the treatment. The statistical analysis included χ2-test and one-way ANOVA.


The results of this study showed that diode laser treatment was more effective in reducing periodontal clinical parameters, lowering MMP-8 levels and reducing the bone loss, compared to the group treated with scaling and root planning, or with a surgical approach.


Diode laser may be considered as an effective alternative for periodontal treatment, with benefits in clinical and biochemical parameters.

Keywords: Periodontitis, Diode laser, Matrix metalloproteinase-8, Periodontal surgery, SRP, Bone-loss.

Article Information

Identifiers and Pagination:

Year: 2020
Volume: 14
First Page: 281
Last Page: 288
Publisher Id: TODENTJ-14-281
DOI: 10.2174/1874210602014010281

Article History:

Received Date: 14/01/2020
Revision Received Date: 21/04/2020
Acceptance Date: 27/04/2020
Electronic publication date: 16/06/2020
Collection year: 2020

© 2020 Sopi et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the, Department of Periodontology and Oral Medicine, University of Pristina Dentistry School, Pristina, Kosovo; Tel: +383 44 310 761; E-mail:

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