The Role of Parathyroid Hormone in Alveolar Bone Resorption on Postmenopausal Women
Susi R. Puspitadewi1, Lindawati S. Kusdhany2, *, Sri Lelyati C. Masulili3, Pitu Wulandari1, Hanna B. Iskandar4, Elza I. Auerkari5
1 Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia.
2 Department of Prosthodontics, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia.
3 Department of Periodontics, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia.
4 Department of Dento-maxillofacial Radiology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia.
5 Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia.
Postmenopausal women exhibit reduced bone mineralization, which causes bone resorption, including that of alveolar bone. Parathyroid hormone has been shown to play a role in alveolar bone resorption.
This study aims to analyze relationships between parathyroid hormone and other factors that may contribute to alveolar bone resorption in postmenopausal women.
This cross-sectional study included 82 postmenopausal women aged 50–74 years, who resided in Central and East Jakarta, Indonesia. Subjects' data were obtained through questionnaires, dental examinations, and blood collection for the examination of parathyroid hormone levels by enzyme-linked immunosorbent assay and using panoramic radiography to measure bone resorption.
Spearman correlation analysis showed a significant correlation between parathyroid hormone level (p = 0.005) and extent of alveolar bone resorption, but age (p = 0.292), menopausal duration (p = 0.244), and number of missing teeth (p = 0.517) were not significantly correlated with the extent of alveolar bone resorption.
Various factors play a role in the mechanism of bone resorption, so knowing the role of each factor is expected to reduce the effects of alveolar bone resorption that occurs in postmenopause. Among the factors investigated in this study, the parathyroid hormone was the sole factor correlated with postmenopausal alveolar bone resorption.
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* Address correspondence to this author at the Department of Prosthodontics, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia;
Tel: +6281284883763; Fax: +622131931412;