The Open Dentistry Journal




ISSN: 1874-2106 ― Volume 13, 2019

Between-Lesion Discrepancies in Terms of Dysplasia, Cell Turnover and Diagnosis in Patients with Multiple Potentially Malignant Oral Lesions



Montebugnoli Lucio*, Gabusi Andrea, Gissi Davide Bartolomeo, Cervellati Fabio , Servidio Dora
Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy

Abstract

Objective:

The present study assessed patients with multiple oral lesions to evaluate the mis-estimation rate in terms of diagnosis and risk of malignant transformation when only one biopsy is performed.

Study Design:

Thirty-five patients presenting at least two white and/or red lesions in different oral mucosa sites with a final diagnosis of leuko/erythroplakias or lichenoid lesions were included, for a total of 70 biopsies.

Results:

Nineteen patients (54%) had at least one between-lesion discrepancy considering the presence/absence of dysplasia (10 patients), normal/high cell turnover (13 patients) or diagnosis (5 patients). Discrepancies were not related to clinical aspect or within-patient similarity of lesions.

Conclusions:

Multiple oral lesions in the same patient can significantly differ in terms of dysplasia, high cell turnover and, even diagnosis. Multiple biopsies are imperative and diagnosis as well as risk of malignant transformation should be formulated for each single lesion rather than for each individual patient.

Keywords: : Leukoplakia, lichenoid lesion, dysplasia, cell turnover, diagnosis.


Article Information


Identifiers and Pagination:

Year: 2013
Volume: 7
First Page: 169
Last Page: 174
Publisher Id: TODENTJ-7-169
DOI: 10.2174/1874210601307010169

Article History:

Received Date: 11/7/2013
Revision Received Date: 11/9/2013.
Acceptance Date: 26/10/2013
Electronic publication date: 29 /11/2013
Collection year: 2013

Article Metrics:

CrossRef Citations:
0

Total Statistics:

Full-Text HTML Views: 1978
Abstract HTML Views: 964
PDF Downloads: 265
Total Views/Downloads: 3207

Unique Statistics:

Full-Text HTML Views: 724
Abstract HTML Views: 622
PDF Downloads: 188
Total Views/Downloads: 1534
Geographical View

© Lucio et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.


* Address correspondence to this author at the Department of Oral Science, University of Bologna, Italy, Via S.Vitale 59 40125 Bologna; Tel: 0512088136; Fax: 051225208; E-mail: lucio.montebugnoli@unibo.it


Endorsements



"Thank you for your magnificent and marvelous support throughout the publication stages. I would like to endorse my experience with you as a Junior Researcher and a recent graduate of the Dental school. Once again Thank you for your Great Help and Guidance throughout the stages of Publication. You guys are a great team and I am proud to be a Young Bentham author."


Asra Sabir Hussain
The University of Edinburgh Business School, UK

"My experience with Bentham Open was a valuable one because the quality of the services and analysis of my paper contributed in improving what we intended to convey to the readers."


José Ricardo Kina
Department of Surgery and Integrated Clinic,
Araçatuba School of Dentistry, São Paulo State University
Brazil

"The Publication Manager was very cooperative and replied my mails and guided me without any delays; however the reviewing process was too long."


Mahtab Memarpour
Prevention of Oral and Dental Disease Research Center,
Department of Pediatric Dentistry, School of Dentistry,
Shiraz University of Medical Sciences, Shiraz,
Iran


Browse Contents



Webmaster Contact: info@benthamopen.net
Copyright © 2019 Bentham Open