The Open Dentistry Journal




ISSN: 1874-2106 ― Volume 13, 2019

Use of Ultrasonic Bone Surgery (Piezosurgery) to Surgically Treat Bisphosphonate-Related Osteonecrosis of the Jaws (BRONJ). A Case Series Report with at Least 1 Year of Follow-Up



Cornelio Blus1, 2, Serge Szmukler-Moncler1, 3, Giulio Giannelli4, Gloria Denotti1, Germano Orrù1, *
1 OBL, Department of Surgical Sciences, University of Cagliari, Cagliari, Italy
2 Private Practice, Torino, Italy
3 Galeazzi Orthopeadic Institute, Department of Odontology, University of Milano, Milano, Italy
4 Department of Odontology, Hospital of Gallipoli, Gallipoli, Italy

Abstract

This preliminary work documents the use of a powerful piezosurgery device to treat biphosphonate-related osteonecrosis of the jaw (BRONJ) in combination with classical medication therapy. Eight patients presenting 9 BRONJ sites were treated, 2 in the maxilla and 7 in the mandible. Reason for biphosphonate (BiP) intake was treatment of an oncologic disease for 5 patients and osteoporosis for 3. The oncologic and osteoporosis patients were diagnosed with BRONJ after 35-110 months and 80-183 months of BiP treatment, respectively. BRONJ 2 and 3 was found in 4 patients. Resection of the bone sequestrae was performed with a high power ultrasonic (piezo) surgery and antibiotics were administrated for 2 weeks. Soft tissue healing was incomplete at the 2-week control but it was achieved within 1 month. At the 1-year control, soft tissue healing was maintained at all patients, without symptom recurrence. One patient with paraesthesia had abated; of the 2 pa-tients with trismus, one was healed, severity of the second trismus abated. This case report series suggests that bone resection performed with a high power ultrasonic surgery device combined with antibiotics might lead to BRONJ healing. More patients are warranted to confirm the present findings and assess this treatment approach.

Keywords: Piezosurgery, Ultrasonic bone surgery, Bone infection, Osteonecrosis, Bisphosphonates, BRONJ, Biofilm, ONJ.


Article Information


Identifiers and Pagination:

Year: 2013
Volume: 7
First Page: 94
Last Page: 101
Publisher Id: TODENTJ-7-94
DOI: 10.2174/1874210601307010094

Article History:

Received Date: 27/2/2013
Revision Received Date: 16/4/2013
Acceptance Date: 30/4/2013
Electronic publication date: 23 /8/2013
Collection year: 2013

Article Metrics:

CrossRef Citations:
0

Total Statistics:

Full-Text HTML Views: 1493
Abstract HTML Views: 1097
PDF Downloads: 350
Total Views/Downloads: 2940

Unique Statistics:

Full-Text HTML Views: 816
Abstract HTML Views: 631
PDF Downloads: 216
Total Views/Downloads: 1663
Geographical View

© Blus et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.


* Address correspondence to this author at the OBL, Università degli Studi di Cagliari, Via Binaghi 4, 09121 Cagliari, Italy. Tel: +39 070 537413; Fax: +39 070 537437; E-mail: orru@unica.it


Endorsements



"Thank you for your magnificent and marvelous support throughout the publication stages. I would like to endorse my experience with you as a Junior Researcher and a recent graduate of the Dental school. Once again Thank you for your Great Help and Guidance throughout the stages of Publication. You guys are a great team and I am proud to be a Young Bentham author."


Asra Sabir Hussain
The University of Edinburgh Business School, UK

"My experience with Bentham Open was a valuable one because the quality of the services and analysis of my paper contributed in improving what we intended to convey to the readers."


José Ricardo Kina
Department of Surgery and Integrated Clinic,
Araçatuba School of Dentistry, São Paulo State University
Brazil

"The Publication Manager was very cooperative and replied my mails and guided me without any delays; however the reviewing process was too long."


Mahtab Memarpour
Prevention of Oral and Dental Disease Research Center,
Department of Pediatric Dentistry, School of Dentistry,
Shiraz University of Medical Sciences, Shiraz,
Iran


Browse Contents



Webmaster Contact: info@benthamopen.net
Copyright © 2019 Bentham Open