The Open Dentistry Journal

ISSN: 1874-2106 ― Volume 14, 2020

Evaluation of Biocompatibility of an Etch-and-Rinse Adhesive System Based in Tertiary Butanol Applied in Deep Cavity

Gilvanely Cardoso Alves1, *, Ana Paula Veras Sobral2
Department of Restorative Dentistry, Faculty of Dentistry, University of Pernambuco, Camaragibe, 1650, Pernambuco, Brazil
2 Department of Oral Pathology, Faculty of Dentistry, University of Pernambuco, Camaragibe, 1650, Pernambuco, Brazil


The aim of this study was to evaluate biocompatibility of an etch-and-rinse adhesive system based in tertiary butanol applied in deep cavity human teeth with approximately 1 mm of remaining dentin by observing histological changes of the pulp tissue of humans at intervals of 01, 07, 14 and 21 days. Twenty third molars with indication for xtraction from patients of both sexes, presenting no systemic alterations were used. Class I cavity was made deeper and then, XP BOND adhesive system and resin Filtek Z250 were applied. The sample was divided into four groups according to the time intervals between the application of adhesive system and extraction. Morphologic criteria analysed considered the presence of hyperemia, type of inflammatory cell response, organization of odontoblast cells layer, organization of pulp tissue and the presence or absence of bacteria. Data were submitted to Fisher Exact Test p> 0.05. We observed mild inflammatory infiltrate, preserved pulp tissue morphology, disorganization of the odontoblast layer in most specimens, as well as absence of bacteria at the intervals of 01, 07, 14 and 21 days. In some cases there was pulp hyperemia. The etchand- rinse adhesive system based in tertiary butanol showed satisfactory behavior in the conditions studied.

Keywords: Bacteria, biocompatible materials, dental adhesives, dental pulp, dentin, hyperemia.

Article Information

Identifiers and Pagination:

Year: 2015
Volume: 9
First Page: 168
Last Page: 173
Publisher Id: TODENTJ-9-168
DOI: 10.2174/1874210601509010168

Article History:

Received Date: 31/12/2014
Revision Received Date: 10/3/2015
Acceptance Date: 24/3/2015
Electronic publication date: 15/5/2015
Collection year: 2015

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© Alves and Sobral; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Restorative Dentistry, Faculty of Dentistry, University of Pernambuco, Camaragibe, 1650, Pernambuco, Brazil; Tel: +55 81 3184-7659; Fax: +55 81 3184-7686; E-mail:


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