The Open Dentistry Journal

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Inhibitory Effect of Alpha-Mangostin on Adhesion of Candida albicans to Denture Acrylic

Ruchadaporn Kaomongkolgit1, *, Kusuma Jamdee2
1 Department of Oral Diagnosis, Faculty of Dentistry, Naresuan University, Phitsanulok 65000, Thailand
2 Dental Science Research Center, Faculty of Dentistry, Naresuan University, Phitsanulok 65000, Thailand


Objective: Candida-associated denture stomatitis is a very common disease affecting denture wearers. It is characterized by the presence of yeast biofilm on the denture, primarily associated with C. albicans. The investigation of agents that can reduce C. albicans adhesion may represent a significant advancement in the prevention and treatment of this disease. This study aims to investigate the effect of alpha-mangostin on the in vitro adhesion of C. albicans to denture acrylic and germ tube formation by C. albicans and to compare its activity with clotrimazole which is a topical antifungal agent commonly used for the treatment of Candida-associated denture stomatitis. Materials and Methodology: Alpha-mangostin was extracted by thin layer chromatography. The effect of alpha-mangostin on adhesion of C. albicans to denture acrylic was determined by using a colorimetric tetrazolium assay and germ tube formation by C. albicans was determined by using the counting chamber. Results: A significant reduction of C. albicans adhesion to denture acrylic was evident after exposure to 2,000 µg/ml of alpha-mangostin for only 15 min. In addition, the 2,000 µg/ml of the alpha-mangostin-treated C. albicans had a reduced ability for germ tube formation. These inhibitory effects of alpha-mangostin were as effective as clotrimazole. Conclusion: Alpha-mangostin has antifungal property against C. albicans by inhibiting the adhesion to denture acrylic and germ tube formation in vitro. These results suggest the potential application of alpha-mangostin as a topical medication or a natural oral hygiene product for treatment of Candida-associated denture stomatitis.

Keywords:: Adhesion, alpha-mangostin, Candida albicans, denture acrylic, denture stomatitis, germ tube formation.

Article Information

Identifiers and Pagination:

Year: 2015
Volume: 9
First Page: 388
Last Page: 392
Publisher Id: TODENTJ-9-388
DOI: 10.2174/1874210601509010388

Article History:

Received Date: 30/7/2015
Revision Received Date: 31/8/2015
Acceptance Date: 8/10/2015
Electronic publication date: 11/12/2015
Collection year: 2015

© Kaomongkolgit and Jamdee; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the (, which permits unrestricted, noncommercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Oral Diagnosis, Faculty of Dentistry, Naresuan University, 99 Moo9 Phitsanulok- Nakornsawan Road, Amphor Mueng, Phitsanulok 65000, Thailand; Tel: +665 966065; Fax: +665 966053; E-mail:

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