G6PC2 rs560887 Gene Variant is Associated with Fasting Blood Glucose in the Admixed Mexican Population
Rodrigo Fernández-Pons1, Paula Costa-Urrutia1, Jacqueline Solares-Tlapechco1, Julio Granados2, Martha E. Rodríguez-Arellano1, *
1 Genomic Medicine Laboratory, Hospital Regional Lic. Adolfo López Mateos, ISSSTE, 1321 Universidad Avenue, Florida, Álvaro Obregón, Mexico City, 01030, Mexico
2 Division of Immunogenetics, Department of Transplants, National Institute of Medical Sciences and Nutrition Salvador Zubirán, 15 Vasco de Quiroga Avenue, Mexico City, 14080, Mexico
In Mexico, type 2 diabetes prevalence is 13.7%, which has a huge impact on Mexican public health. There is an urgent need to focus on the prevention of pre-diabetes to decrease the likelihood of type 2 diabetes onset. Gene variants predisposed to increase Fasting Blood Glucose (FBG) and glycosylated hemoglobin (HbA1c) levels could be helpful for prevention purposes. This study aimed to analyze the association of the G6PC2 rs560887 variant with pre-diabetes in a Mexican-Mestizo population.
A cross-sectional case-control study was performed in 960 Mexican Mestizos participants. The association of G6PC2 rs560887 with pre-diabetes was analyzed by logistic regression and with Fasting Blood Glucose (FBG) and glycosylated hemoglobin (HbA1c) by linear regression.
The G6PC2 rs560887 variant was significantly associated with FBG (β -1.80, p=0.03), but not with HbA1c or the presence of pre-diabetes.
The G6PC2 rs560887 loci could be a potential early marker of type 2 diabetes.
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* Address correspondence to this author at Genomic Medicine Laboratory, Hospital Regional Lic. Adolfo López Mateos, ISSSTE, 1321 Universidad Avenue, Florida, Álvaro Obregón, Mexico City, 01030, Mexico; e-mail: email@example.com