The Open Diabetes Journal

ISSN: ― Volume ,

G6PC2 rs560887 Gene Variant is Associated with Fasting Blood Glucose in the Admixed Mexican Population

Rodrigo Fernández-Pons1, Paula Costa-Urrutia1, Jacqueline Solares-Tlapechco1, Julio Granados2, Martha E. Rodríguez-Arellano1, *
1 Genomic Medicine Laboratory, Hospital Regional Lic. Adolfo López Mateos, ISSSTE, 1321 Universidad Avenue, Florida, Álvaro Obregón, Mexico City, 01030, Mexico
2 Division of Immunogenetics, Department of Transplants, National Institute of Medical Sciences and Nutrition Salvador Zubirán, 15 Vasco de Quiroga Avenue, Mexico City, 14080, Mexico



In Mexico, type 2 diabetes prevalence is 13.7%, which has a huge impact on Mexican public health. There is an urgent need to focus on the prevention of pre-diabetes to decrease the likelihood of type 2 diabetes onset. Gene variants predisposed to increase Fasting Blood Glucose (FBG) and glycosylated hemoglobin (HbA1c) levels could be helpful for prevention purposes. This study aimed to analyze the association of the G6PC2 rs560887 variant with pre-diabetes in a Mexican-Mestizo population.


A cross-sectional case-control study was performed in 960 Mexican Mestizos participants. The association of G6PC2 rs560887 with pre-diabetes was analyzed by logistic regression and with Fasting Blood Glucose (FBG) and glycosylated hemoglobin (HbA1c) by linear regression.


The G6PC2 rs560887 variant was significantly associated with FBG (β -1.80, p=0.03), but not with HbA1c or the presence of pre-diabetes.


The G6PC2 rs560887 loci could be a potential early marker of type 2 diabetes.

Keywords: Pre-diabetes, Fasting blood glucose, Glycosylated haemoglobin, G6PC2 rs560887, Mexican-mestizo, Glycolysis.

Article Information

Identifiers and Pagination:

Year: 2020
Volume: 10
First Page: 26
Last Page: 29
Publisher Id: TODIAJ-10-26
DOI: 10.2174/1876524602010010026

Article History:

Received Date: 22/3/2020
Revision Received Date: 1/7/2020
Acceptance Date: 26/7/2020
Electronic publication date: 18/09/2020
Collection year: 2020

© 2020 Fernández-Pons et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at Genomic Medicine Laboratory, Hospital Regional Lic. Adolfo López Mateos, ISSSTE, 1321 Universidad Avenue, Florida, Álvaro Obregón, Mexico City, 01030, Mexico; e-mail:

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