RESEARCH ARTICLE
Rodent Models of Diabetes and Diabetes Complications
Eleazar Shafrir1, Yasunori Kanazawa2, *
1 Hadassah University Hospital and Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
Article Information
Identifiers and Pagination:
Year: 2011Volume: 4
First Page: 15
Last Page: 17
Publisher Id: TODIAJ-4-15
DOI: 10.2174/1876524601104010015
Article History:
Received Date: 19/05/2010Revision Received Date: 08/12/2010
Acceptance Date: 15/01/2011
Electronic publication date: 28/3/2011
Collection year: 2011
© Shafrir et al.
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
The rats listed here have been extensively studied as animal models of diabetic complications and their pathogenesis. The results of studies with the SHROB, JCR:LAcp and OLETF rats are instructive in understanding macro vascular diseases. The Cohen, GK, SHROB and OLETF rats are model of diabetic kidney disease. The SHROB rat might also be useful for diabetic retinopathy study. The importance of mitochondrial inactivity in diabetes was demonstrated with the ZDF rat. The heterogeneous complication models may be useful to understand pathogenesis, prevention and treatment of complications of diabetes mellitus.